This should be a non-brainer – ie. catering to the non-English users of the Web.<p>I wish I could say we were smart enough to have taken that in to account when we started, but, like most, we were oblivious to the fact, and only ended up awakening to the opportunity by virtue of our community leading the way, with their use and volunteer localizations of our offering.<p>At this point, about 50% of our users are non-English (our offering is available in 30 languages - again, all localized by volunteers).<p>We are monetizing in 40 countries, using PayPal to sell low cost subscription based web services and virtual goods. In order of sales - US, UK, Canada, Italy, Germany, Spain, Japan, France, and Brazil.<p>So, my best advice to all those running a start-up - think global. You will be able to monetize once you get there.