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Blood of world’s oldest woman hints at limits of life

153 点作者 rottyguy将近 9 年前

12 条评论

adevine将近 9 年前
Thanks for posting this, I thought it was fascinating research. This sentence in particular was a surprise to me:<p>It’s estimated that we’re born with around 20,000 blood stem cells, and at any one time, around 1000 are simultaneously active to replenish blood.<p>I was surprised the number was so low. Interesting to think this relatively small number of little factories has to sustain us throughout life.
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raverbashing将近 9 年前
Now the real question is: when are the telomeres rebuilt?<p>Because every individual started with one single cell, from a father and mother cells that also underwent cell division<p>Hence at some point in time these telomeres get rebuilt&#x2F;replenished.
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reasonattlm将近 9 年前
It helps to think about the basics when talking about telomere length and cell behavior.<p>1) Telomeres shorten with each cell division in ordinary somatic cells. When they get too short, cells self-destruct or stop dividing. So average telomere length in tissue is a function of cell division rates.<p>2) Stem cells support their associated tissue type by providing new cells with long telomeres. Thus average telomere length is also a function of cell replacement rates.<p>3) Average telomere length is at present usually measured in white blood cells. The rates of division and replacement here are tied in to many factors, including general health, autoimmunity, infection, state of the thymus, and so on and so forth. It would probably be better to use another tissue, such as skin, but that isn&#x27;t the way things worked out in practice.<p>So telomere length is far removed from first causes in aging - it is largely a marker, largely of stem cell function in most tissues, but in immune cells with their varying rates of division according to circumstances, also a marker of all sorts of other unrelated or partly related things.<p>If telomere length is globally extended, you have cells that can divide more often without the need for stem cell support, and you also have more energetic stem cells. But those cells dividing more often are more damaged on average. This may or may not be important enough to do bad things such as raise cancer risk significantly in our species: more data needed.
4bpp将近 9 年前
Blood storage for autologous transfusion has apparently already been a thing for a while[1] and has been indicated to be effective in animal experiments[2], but as far as I can tell, no provider is willing to store it for more than about 20 years (and what is stored may not in fact contain stem cells, but rather only something that spurs the existing ones into activity). My general impression is that the medical community&#x27;s moral gut reaction is unfavourable towards the idea.<p>[1] <a href="http:&#x2F;&#x2F;www.bloodbook.com&#x2F;storage.html" rel="nofollow">http:&#x2F;&#x2F;www.bloodbook.com&#x2F;storage.html</a> [2] <a href="https:&#x2F;&#x2F;www.newscientist.com&#x2F;article&#x2F;mg22329831-400-young-blood-to-be-used-in-ultimate-rejuvenation-trial&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.newscientist.com&#x2F;article&#x2F;mg22329831-400-young-bl...</a>
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blackbagboys将近 9 年前
IIRC there was a doctor posting in other threads about his bone-marrow stem cell banking startup. My understanding was that these stem cells were stored when young, and could be multiplied in a lab environment and then re-injected therapeutically (to cure MS or arthritis or whatever). Would these kind of banked stem cells (say, banked in one&#x27;s early or late twenties) also potentially assist with life extension?
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1dKFpcxn将近 9 年前
Does this mean that people who give blood are losing valuable stem cells and wont live as long?
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zeristor将近 9 年前
Hmmm.<p>From an engineering perspective what are the MTBFs for the various human components; are a dearth of White blood cells a prime reason for aging and death?<p>Great progress has been made in genetics surely one could read the DNA of a few thousand cells and have an extremely strong confidence of what the unmutated DNA for a person once was.<p>And from this you could make new white blood cells et voila.<p>This all seems rather Blade Runnery. Mind you there would be societal problems with people who can live much older: slowing of cultural evolution, career blocking, and monopolising property; we&#x27;ve got that now but it would get worse.<p>I&#x27;m worried about the Brexiters kicking out the metric system;that and fascist tyranny.
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sharpercoder将近 9 年前
Does this mean donating blood reduces your lifespan?
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codecamper将近 9 年前
If stem cells are finite &amp; small in number. And you have some removed to be preserved for later life... Then maybe you will have problems due to having fewer stem cells?
ilaksh将近 9 年前
Stem cells are a part of it, but there is much more to it. For a realistic, comprehensive, and much more informed approach to aging research, see <a href="http:&#x2F;&#x2F;www.sens.org" rel="nofollow">http:&#x2F;&#x2F;www.sens.org</a>.
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ape4将近 9 年前
So luck is the key. If your mutations are good you live a long healthy life.
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tr1ck5t3r将近 9 年前
Vitamin D derived from sunshine notably UVB reduces the shrinkage of the telomeres.
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