I think the main issues here are ones of capital scale and efficiency. I believe 37Signals' tenets work well for low headcount, extremely capital-efficient businesses such as software development, hedge fund management, or specialty insurance.<p>Unfortunately, there are many enterprises (drug research, agriculture, smelting, office construction, theme parks, waste processing, private space exploration, etc.) which are fundamentally dependent on large amounts of capital both during the start-up phase as well as to ensure daily continuity of operations.<p>Most of these capital intensive business also demand a reasonably large staff to support these daily workflows.<p>With a larger staff comes the increasing probability that one bad apple will be hired. Just one bad apple can bring an entire enterprise down without a reasonable set of security and trust-limiting thresholds on capital expenditures and workflow control. The Union Carbide chemical spill in Bhopal and the Barings bank collapse come immediately to mind.<p>A prominent COO once told me that for every 100 hires, he expected to pick-up 1 bad apple every 2 years. In his context a "bad apple" was someone whom, over time, would repeatedly and deliberately attempt to criminally defraud, sabotage, or publicly discredit the company.<p>With those odds, basic human nature, and capital-intensive business economics, it's not hard to see why these enterprise's mores on debt and individual trust run counter to 37Signals' philosophy.