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FSU research team makes Zika drug breakthrough

147 点作者 nikunjk超过 8 年前

7 条评论

nonbel超过 8 年前
Strange, apparently they only blinded themselves for two western blots that didn&#x27;t even deserve a place in the main paper. I have found this is an <i>extremely</i> common issue with virology studies:<p>&gt;&quot;The screening of two subsets of compounds for antiviral activity (Supplementary Fig. 2a and Supplementary Fig. 4b) was performed in a blinded manner, whereas all other experiments were performed in a nonblinded manner.&quot; <a href="http:&#x2F;&#x2F;www.nature.com&#x2F;nm&#x2F;index.html" rel="nofollow">http:&#x2F;&#x2F;www.nature.com&#x2F;nm&#x2F;index.html</a><p>Also, I searched for the virus strain they used and the first thing I clicked on claimed it has issues with relevance in vivo:<p>&gt;&quot;Anyone who is using viruses termed ZIKV MR766 needs to carefully examine the sequence composition of their stocks. Multiple viruses all termed MR766 may have different sequences and biological properties.In the case of the MR766 we are using in our studies, there is a deletion in the challenge stock that is strongly selected against quickly in vivo.&quot; <a href="https:&#x2F;&#x2F;zika.labkey.com&#x2F;wiki&#x2F;OConnor&#x2F;ZIKV-002&#x2F;page.view?name=17301_mr766_challenge_comparison" rel="nofollow">https:&#x2F;&#x2F;zika.labkey.com&#x2F;wiki&#x2F;OConnor&#x2F;ZIKV-002&#x2F;page.view?name...</a>
devy超过 8 年前
TL;DR, the identified&#x2F;named drug that may be repuposed to prevent Zika virus is called Niclosamide, wikipedia has already been updated[1] with its side benefit :)<p>Nicolsamide is also listed as WHO&#x27;s &quot;one of the most important medications needed in a basic health system.&quot;[1]<p>There should be more drug repurposing researches to be done but it&#x27;s probably profit-prohibiting for the big pharmas :(<p>[1] <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Niclosamide" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Niclosamide</a>
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nolepointer超过 8 年前
Yep, surprisingly, research is done here. We don&#x27;t just have a football team.
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dmritard96超过 8 年前
saw this on my fb feed this morning and tbh, was glad the fsu actually got some headline room. personally not connected to fsu but I see so many MIT... that some of these other institutions doing big things get lost in the shuffle.<p>also really liked the search strategy. first try all the things already approved by the fda to find something, even if not 100% ideal since its so much faster than seeking fda approval of something new. Curious how this will change in the near future given the prevalence of deep learning and with some of the opentrons type testing systems.
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maxerickson超过 8 年前
If anyone else was surprised by the 584 pregnant women living in the US that are believed to have been infected, the CDC has the same number here:<p><a href="http:&#x2F;&#x2F;www.cdc.gov&#x2F;zika&#x2F;geo&#x2F;pregwomen-uscases.html" rel="nofollow">http:&#x2F;&#x2F;www.cdc.gov&#x2F;zika&#x2F;geo&#x2F;pregwomen-uscases.html</a>
dmatthewson超过 8 年前
Sounds great. When will we see reputable validation of their extraordinary claims?
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iptables超过 8 年前
FUCK SHIT UP team