There was a time (just over a hundred years ago) when people thought that there was nothing more to learn about the universe. There were just these two little problems that needed explained...<p>Now, that was because they thought they understood everything there was to know, not because they worried that there were limits beyond which they could not know. But, as the article says, trying to guess how much we will learn (or not learn) in the next, say, 100 years, is a very hazardous business.