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80% of current drug applications in China failed to meet analysis requirements

127 点作者 ting_bu_dung超过 8 年前

9 条评论

projektfu超过 8 年前
In the couple years I spent doing biology research, about 8 years ago, I was skeptical of most research from China because it already had a reputation already of being untrustworthy. But why stop at China?<p>I spent a good part of a year trying and failing to replicate an English study, and looking around for materials referenced in another study that simply don&#x27;t exist, finally being told by the principal on that study that they mischaracterized the materials in the paper. Sometimes when you get the results you are hoping for, you publish, and you don&#x27;t care if they were wrong, right?<p>Perhaps it would be better if scientists generally took a more skeptical view of others&#x27; publications and tried to replicate them in house. At conferences, instead of asking, &quot;Where do we go from here&quot;, with the first study, ask, &quot;What do I need to do to replicate this?&quot;
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eveningcoffee超过 8 年前
Considering past occurrences <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;2008_Chinese_milk_scandal" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;2008_Chinese_milk_scandal</a> and general behaviour in online market places (my last experience was that the product was advertised to be shipped from Germany (expect fast delivery), but arrived a month later from China) then it should not come as very big surprise (I am not saying that this is normal or acceptable, but that it is not very surprising).<p>My question is that what is the cause of this general fraudulent behaviour? Does it have some historical roots? Does it come from lack of actual functioning oversight?<p>Another anecdotal case: try asking for directions in China. Even when person does not know the correct directions, they do not mind to direct you, and when confronted, they refuse to admit that they do not know. Is this mindset result of constant fear of repressions, or it runs deeper into the history of the society (say it is also present in Taiwan?).<p>I am not accusing anybody in anything, I just would like to understand.
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brudgers超过 8 年前
<i>Radio Free Asia (RFA) is a private, nonprofit international broadcasting agency of the United States government[2] that broadcasts and publishes online news, information, and commentary to listeners in East Asia while &quot;advancing the goals of U.S. foreign policy.&quot;</i><p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Radio_Free_Asia" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Radio_Free_Asia</a><p>The source cited is Radio Free Asia not the report itself. Radio Free Asia does not link to any additional sources.<p>That is not to say that the story is inaccurate, but rather that the claims are not well substantiated and that the source is not apolitical.
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Odenwaelder超过 8 年前
In chinese culture, losing one&#x27;s &quot;face&quot; is one of the worst things that can happen to a person. I&#x27;m wondering whether the fact that 80% of data has been fabricated is a result of that. As in, &quot;I have to make my findings significant to not lose my face&quot;, or, &quot;Presenting negative findings to my superior will make me lose my face&quot;. Maybe someone more familiar with this culture could elaborate.
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canada_dry超过 8 年前
No wonder wealthy Chinese go out of their way to buy not-made-in-China food and medicine.
DanielBMarkham超过 8 年前
Science is having an astounding crisis -- I don&#x27;t think there&#x27;s been anything like it in history before.<p>If this is true about Chinese clinical data? More generally, if there is any simple tag that covers fraud at this scale? Other people working under that tag will experience deleterious effects for years to come.<p>The only way I see out of this is a rigorous, self-imposed body of standards. Even then I&#x27;m not sure that this will be sufficient.<p>Think of all those people, all of that money, all of the hundreds of thousands of hours of research. For nothing. Actually, it&#x27;s worse than nothing because it&#x27;s been flooding the system with fake data.
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tlb超过 8 年前
It mentions 1622 current clinical trials. Of those, how many would be expected to be approved in a rational system?<p>I wonder if the huge %age is due to a lot of low-quality applications mixed in with the serious ones. If the barrier to apply is sufficiently low, you would expect a Sturgeon&#x27;s law dynamic.
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ksk超过 8 年前
Title should make it clear that this article is about currently pending applications, not about all clinical trials.
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msie超过 8 年前
Ting bu dung...
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