Been using angular 2.0 for a short while and it's been pretty great. Had to get used to the () [] and [()] syntax but it's so far been the best "all included" experience building web apps I had (from table layout and asp in the last decade through jquery, backbone and angular 1.0). Used it with systemjs initially then moved to angular-cli and webpack. It just works. ng new, ng build, ng serve. No need for gulp/grunt/bower/browserify/yeoman. Built in support for scss. Built in support for typescript. For an occasional web app builder like me who can't keep up with the latest trends all the time this has been the best one stop shop experience so far. The fact that typescript @types are all in npm as well and I can simply do import 'lodash' and just use it is what I always dreamed about front end web development. Simply do ng new and you got a working front end web app with tons of opinionated best practices/tooling and no additional libraries to learn.
I'm sure there is a downside to just taking the easy route here but for just an occasional internal web app this is by far the easiest experience I had with any front end framework. Kudos to the angular team.