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Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

156 点作者 miraj超过 7 年前

7 条评论

guyt00超过 7 年前
Problems with this terrible title:<p>1. In vitro petri dish testing is a million light years away from showing a compound works in humans.<p>2. This is a particularly bad problem in brain diseases as getting your compound to cross the blood-brain barrier in correct therapeutic quantities is extremely difficult.<p>3. We have lots of direct antibodies that kill beta amyloid in vivo that are very advanced in human trials. The problem now is that they often cause micro-damage when removing various forms of amyloid protein or have been shown to be administered far too late when the damage is already done.<p>4. It&#x27;s still not clear that beta amyloid is even the main causal agent of Alzheimers!<p>In general, if you see someone touting a low effort, pre-clinical study as major medical breakthrough, start hitting the downvote button. I&#x27;m disappointed this even got to the main page.
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chillingeffect超过 7 年前
article is a value-added summary of: <a href="https:&#x2F;&#x2F;www.sciencedaily.com&#x2F;releases&#x2F;2016&#x2F;06&#x2F;160629095609.htm" rel="nofollow">https:&#x2F;&#x2F;www.sciencedaily.com&#x2F;releases&#x2F;2016&#x2F;06&#x2F;160629095609.h...</a><p>which is based on this press release: <a href="http:&#x2F;&#x2F;www.salk.edu&#x2F;news-release&#x2F;cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.salk.edu&#x2F;news-release&#x2F;cannabinoids-remove-plaque-...</a><p>original paper here: <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;npjamd201612" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;npjamd201612</a> &quot;Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids&quot;<p>original paper: <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;npjamd201612.pdf" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;npjamd201612.pdf</a>
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kinleyd超过 7 年前
Hmm, seems like it&#x27;s time to seriously consider extracting some THC and CBD. I&#x27;m looking at this: <a href="https:&#x2F;&#x2F;magicalbutter.com&#x2F;" rel="nofollow">https:&#x2F;&#x2F;magicalbutter.com&#x2F;</a>. Anyone have some experience with this type of gear?
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cat199超过 7 年前
wow.. who would have ever thought that MJ would be <i>good</i> for memory..
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pmiller2超过 7 年前
A very exciting petri dish result! If this actually works in an animal model, it could be a true breakthrough. I am wondering if THC <i>in vivo</i> might undergo some kind of subtle metabolism after being ingested or smoked so that it still binds to cannaboid receptors, but doesn&#x27;t affect beta amyloid.
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jjuel超过 7 年前
The problem is this will never get funded or passed due to the Big Pharma lobbyists.
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maxxxxx超过 7 年前
Marijuana seems to be approaching the peak of inflated expectations of the Hype Cycle <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Hype_cycle" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Hype_cycle</a>. Pretty much nothing can&#x27;t be healed by smoking weed. Let&#x27;s hope it soon goes back to normalcy.