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DIY recipes to make your own expensive pharma drugs

100 点作者 sprague超过 7 年前

16 条评论

dang超过 7 年前
Discussed extensively at <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=15467379" rel="nofollow">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=15467379</a>, still on the front page.
hprotagonist超过 7 年前
From the frontmatter: &gt;&quot;A toast to the dead, for children with cancer and AIDS&#x2F; A cure exists, and you probably could have been saved.&quot;<p>I appreciate the can-do attitude of biohacking, but this is A. flatly wrong and B. a grave insult to every working pharma chemist.<p>from <a href="http:&#x2F;&#x2F;blogs.sciencemag.org&#x2F;pipeline&#x2F;archives&#x2F;2014&#x2F;04&#x2F;15&#x2F;sweet_reason_lands_on_its_face" rel="nofollow">http:&#x2F;&#x2F;blogs.sciencemag.org&#x2F;pipeline&#x2F;archives&#x2F;2014&#x2F;04&#x2F;15&#x2F;swe...</a>:<p><i>Looking someone in the eye and asking them if they really are accusing me of watching some of my family members die from diabetes, cancer, and heart disease while I was hiding the cures and collecting my paycheck is an uncomfortable conversation, but I’ve had it a few times.<p>The only counterattack has been that no, they’re not saying that I personally have these things in my desk drawer, it’s the higher-ups, you know, them.<p>“So how have I been working on these diseases for 25 years without rediscovering any of these cures?” I ask, and that generally winds things up. But I like to think (or to kid myself) that I’ve planted a slight seed of doubt.<p>You need as much conviction in your voice as the quacks have, though, and that’s not easy, because they have a lot. Science has the evidence on its side, naturally, and that’s a lot, but conspiracy theorists and their friends have something to believe in, and that’s a very strong part of human nature indeed.</i>
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hvindin超过 7 年前
As an Australian, i.e. someone who lives in a country which doesn&#x27;t assume that being poor is a good enough reason for someone to be allowed to die. As well as the brother of a scientist who often runs experiments involving the synthesis of new drugs, I had a torrent of extreme reactions to seeing that this site exists.<p>1. My immediate reaction was holy shit no, if a situation exists where your countrymen are trying to hack together potentially lethal drugs and medical procedures because you don&#x27;t have facilities in place to save them, then whatever political decisions you are making, whatever trade deals you are signing, whatever wars you are fighting: stop ALL OF THAT SHIT AND FIX THIS FIRST.<p>2. Oh my god what a terrible way to die. I understand that this site is probably well-intentioned. I know that for someone with access to a pharmaceutical lab and who has experience in the small-scale manufacture of drugs intended for consumption by living creatures (experiments) including humans (clinical trials) it may make sense that we could just synthesise our own drugs. But failing to recognise that there are very real and very likely scenarios where people will die because you (or someone with your expertise) are not on hand to help them immediately if they fuck up.<p>I can&#x27;t help but think that the existence of this site is a net harm to the world, there&#x27;s just no way the risk calculation is the same between a chemical engineer and a regular chap who needs medication as to the possibility of just making it at home. Making it seem like this is a thing you think that you should do just sounds like bad advice.<p>But on the other hand, I&#x27;m so appalled by the ability of America as a nation to do terrible things such as let its citizens die from treatable illness, that this kind of makes sense. It just feels like the wrong problem to be solving.<p>I mean, how about focusing on fixing the broken medical system, avoiding killing all the people who aren&#x27;t white and making it just a little harder for insane people to get guns. While you&#x27;re at it, you might even want to try and drop &quot;racist as shit&quot; from the assumptions of the rest of the world about your country.
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refurb超过 7 年前
Go talk to an organic chemistry PhD student and ask them how likely this is to work. The answer is &quot;not likely&quot;. Organic synthesis is difficult even for a trained expert. Hell, even the pharmaceutical manufacturers screw it up sometimes.<p>And that&#x27;s not even thinking about the possibility of unintended side reactions that create toxic products. Do a google search for &quot;MPTP&quot; if you want to read about amateur synthesis. A ton of people ended up with Parkinson&#x27;s disease due to a bad synthesis.
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hmwhy超过 7 年前
I think home made reactors is a terrible idea. As a few comments have already pointed out, many things could go wrong in a synthesis—the fact that are trusting users to make a reactor to begin with is already an awful idea.<p>In addition, chemists are not just trained to “make stuff”—the average person isn’t trained to handle toxic chemicals. Even if a person is aware of how to handle chemicals properly, accidents really do happen.<p>A good example is that bromoethane is listed as a starting material for Daraprim on this website—Google for the MSDS for this chemical and you will know what I mean.<p>Then there are the clean up and analyses after you have made something. No, it’s not as simple as checking melting points.<p>I appreciate that people try to take it into the hands to fight what I personally consider to be unfair, but I think this is not how it’s done and it’s a terrible idea.
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peteretep超过 7 年前
Always worth remembering “A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine“<p><a href="http:&#x2F;&#x2F;heterodoxy.cc&#x2F;meowdocs&#x2F;pseudo&#x2F;pseudosynth.pdf" rel="nofollow">http:&#x2F;&#x2F;heterodoxy.cc&#x2F;meowdocs&#x2F;pseudo&#x2F;pseudosynth.pdf</a>
mrkgnao超过 7 年前
NurdRage, a relatively popular YouTuber, also replicated the Epipencil experiment on his channel.<p><a href="https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=aoQajOum6wA" rel="nofollow">https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=aoQajOum6wA</a><p>The reason I&#x27;m bringing him up is that he synthesised Daraprim (pyrimethamine) from domestically-available materials over a period of ~2 years.<p><a href="https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=ddCuWX4vtOA&amp;list=PLU79801KtVAU1XsTwHaKkqQoBgz_VYmPS" rel="nofollow">https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=ddCuWX4vtOA&amp;list=PLU79801KtV...</a><p>There&#x27;s an NMR spectrum at about 12:08 in the last video in the playlist, which shows that he doesn&#x27;t quite have medical-grade Daraprim, and that he&#x27;d need a lot of purification to get there.
Mz超过 7 年前
I boggle that a) this site exists and b) it is getting any traction on HN. Because this is guilty of all the things I have been accused of in terms of being irresponsible and dangerous and possibly profit motivated.<p>How do sites like this seemingly thrive (Goop!) when doing something really conservative like talking about food chemistry and germ control is such insane drama? I just don&#x27;t get it.<p>(I have a form of cystic fibrosis and have spent a lot of years getting stronger and healthier using primarily dietary and lifestyle changes. I used to be really open about that, which was nothing but an ugly shit show every step of the way.<p>I am probably making a huge mistake to comment on that. There seems to be zero path forward for me. I genuinely don&#x27;t understand it.)
mbroncano超过 7 年前
Maybe I&#x27;m reading too much into it, but I&#x27;d like to suggest that possibly something is seriously wrong in our society if we need to revert to home made drugs instead of what pretty much the rest of the civilized world does: providing them to their citizens by means of a single payer, universal health care system.
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fernly超过 7 年前
Make your own meds at home? What could POSSIBLY go wrong?
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agotterer超过 7 年前
Michael Laufer (One of the guys behind this project) gave a talk at HOPE 2016 about making and torrenting Daraprim. It is as an excellent talk and worth checking out. <a href="https:&#x2F;&#x2F;youtu.be&#x2F;NjQ7yLmeqUw" rel="nofollow">https:&#x2F;&#x2F;youtu.be&#x2F;NjQ7yLmeqUw</a>
jeremy_wiebe超过 7 年前
Didn’t read the article but the headline immediately reminded me of this: <a href="http:&#x2F;&#x2F;www.cbc.ca&#x2F;radio&#x2F;thisisthat&#x2F;fake-ontario-trees-teen-suit-trend-unicycle-cop-handmade-pharmaceuticals-1.3791725&#x2F;handmade-homemade-pharmaceuticals-all-the-rage-at-new-brunswick-farmers-market-1.3791753" rel="nofollow">http:&#x2F;&#x2F;www.cbc.ca&#x2F;radio&#x2F;thisisthat&#x2F;fake-ontario-trees-teen-s...</a><p>“Homemade, handmade pharmaceuticals”.
pizza超过 7 年前
Good on them for including a blueprint of Naloxone
tyingq超过 7 年前
Aside from being a bad idea there is no actual content describing how to synthesize anything. Any chemists about? Is it even plausible for the medications he&#x27;s talking about, like Hep C treatments?
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api超过 7 年前
When we built the Internet this is the future we thought we were building. More please.
Ice_cream_suit超过 7 年前
&quot;A DIY Epinephrine Autoinjector for just over $30&quot;<p>Do it wrong, and a child dies...