Neat. I've been fasting for an average of 6 days at a time, once-a-month. It's hell for the first 3 days but it gets better.<p>Related but different, perhaps someone with a bio/med background knows: Regarding the metformin FDA Phase 4 clinical trial for life extension <i>and</i> a conflicting recommendation from my PCP that metformin (1500 mg) has a significant risk of injury from acute hypoglycemia in those (like yours truly) <i>without</i> type-2 diabetes but <i>being</i> overweight (about 20%). I didn't see anything in the literature or box warnings about <i>common</i> hypoglycemia risks, especially in good liver & kidney functional patients, and the body can regulate glucose with a panoply of pathways. Seems to me, metformin looks like it has massive potential to benefit many people to up-regulate healthy pathways, but only if doctors understood its limitations and capabilities in settings outside of diabetes. Or am I missing or wrong about something?<p><a href="https://clinicaltrials.gov/ct2/show/NCT02432287" rel="nofollow">https://clinicaltrials.gov/ct2/show/NCT02432287</a><p><a href="https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral/metformin-oral/details/list-sideeffects" rel="nofollow">https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral...</a><p><a href="https://www.drugs.com/sfx/metformin-side-effects.html" rel="nofollow">https://www.drugs.com/sfx/metformin-side-effects.html</a>