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Ibuprofen alters human testicular physiology including testosterone production

185 点作者 inglondon超过 7 年前

6 条评论

tejasmanohar超过 7 年前
This was discussed ~3 weeks ago. Here&#x27;s the thread-- <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=16101072" rel="nofollow">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=16101072</a>
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reallymental超过 7 年前
I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of <i>some</i> raw data that I can get my hands on, just to see if I can.<p>Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me!<p>What&#x27;s wrong with &quot;Here&#x27;s the raw data, here&#x27;s how we measured it, Here&#x27;s how we&#x27;ve shown the data, and look you can see for yourself that we are right! oh and the data costs $$$ much.&quot; ?<p>I understand experiment reproducibility is not incentivised in academia, but then why make it hard for an external party to reproduce it&#x2F;study it?<p>Do we have to go through the usual &quot;Contact the academic, maybe they answer, and maybe you&#x27;ll get the same (version of) data that they used in that experiment, maybe you&#x27;ll have to go through Elsevier, oh and you must have .edu&#x2F;.ac.uk address to be taken seriously through all those requests.&quot;<p>What a chore. Just adds to the hate towards &#x27;experts&#x27; and their opinions.
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mdomans超过 7 年前
This isn&#x27;t really huge news, technically speaking. Any anti-inflammatory drug will have negative net impact on your body function. For a while we know now that NSAIDs alter ROS levels in response to injury and in fact any normal process. NSAIDs also have negative impact on training adaptation or cell death due to overexpression of ROS. So no - taking overabundant levels of oral NSAIDs isn&#x27;t going to be good for you and that&#x27;s why topical NSAIDs make sense in cases of joint pain, tough they&#x27;re not as convenient.<p>Note: I remember taurine had protective effect on testicular function in men treated in 19-nor derivatives. Maybe worth checking out if it does so also for ibuprofen :)
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deftnerd超过 7 年前
I&#x27;ve been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn&#x27;t totally fit though so I felt like there was something else that was a major contributor.<p>Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It&#x27;s also a big deal because Tylenol has been pushed aside for the last 20 years as being more unsafe for children than Ibuprofen.
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amelius超过 7 年前
Is this a permanent effect, or does T production return to normal after stopping the drug?
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raverbashing超过 7 年前
While the results do matter, this is probably being blown out of proportion<p>&gt; One group of subjects received ibuprofen, 2 × 600 mg&#x2F;d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk<p>Yeah, that&#x27;s <i>a lot</i> of Ibuprofen for a long time
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