A lot of ad networks suck big time. AdSense is decent if your site is content oriented, e.g. articles about specific thigns or whatever. If you run a service like I do however (getclicky.com) then these types of ad networks don't work at all. Plus AdSense seems to be real anal and your account can get canned at any time without explanation and no chance of getting it back. Wow, that's fun.<p>A lot of ad networks also have a 30-90 day pay delay which sucks when you're just getting started.<p>If you have a decent amount of traffic, say at least 2,000 daily visiors or 20,000 daily page views, you should be able to sell ads directly without any problem. You set your own price and cut out the middle man and swim in the money.<p>However the problem with this is that you have to deal with inquiries all the time, worry about billing (unless you have an automated billing system setup already for something else that you can integrate ads into as well). So this service came along called BuySellAds.com that we now use on getclicky.com for our ads. We still set the price and decide how many ads we want to sell, what size, etc. And they deal with all teh billing and take a 25% cut. I think that's reasonable for the automation they provide. Before we switched to them I was dealing with advertising billing and inquiries for many hours every month. They also allow you to cash out at any time. Because of this I highly recommend the service.