best is something thats very difficult to quantify really, i guess it depends entirely on the application and setting. I have had vast experience which psychoactives, a lot substances more than most people could even name however i have never had anything that id consider a meaningful or spiritual experience.<p>Thats not to say i havent had fun, there are a lot of interesting and enjoyable experiences to be had and i can honestly say that despite having experimented with well over 100 unique chemicals i have never had a single bad experience