There are many different strains, with different potency, which have differing terpenes, which may or may not change how it affects your body.<p><i>Your absolute best bet is to talk to a doctor experienced in prescribing medical marijuana - and work with them.</i> When using medicinally, marijuana is similar to other prescriptions in the sense that you need to find the "correct" dosage and mixture that works for your body and your issues. This also includes experimenting with different forms of delivery (vape, food, oils, sprays, capsules, etc.) My dear mother spent close to a year visiting with her doctor to narrow down a strain, dosage, and delivery method to help cope with her RLS.<p>Anecdotally speaking, I have not had the experiences you described. In my non-medical opinion, it sounds like you may have taking too strong of a dosage, and may have had a predominately body-high focused strain. In general, Sativa's are more head-focused while Indica's are more body-focused. This is not set in stone, however; there are Indica's with a strong head-high and Sativa's with a strong body-buzz. And with cross-breeding and all of the resulting strains, it's not nearly as useful to think in purely Sativa vs. Indica anymore. But, the general rule may help you narrow down to a more palatable strain if you choose to keep experimenting.<p>Combining your two experiences (weird high, and CBD induced migraines), it may be that you, unfortunately, do not react well to marijuana.