TE
科技回声
首页24小时热榜最新最佳问答展示工作
GitHubTwitter
首页

科技回声

基于 Next.js 构建的科技新闻平台,提供全球科技新闻和讨论内容。

GitHubTwitter

首页

首页最新最佳问答展示工作

资源链接

HackerNews API原版 HackerNewsNext.js

© 2025 科技回声. 版权所有。

Every Cancer Patient Is One in a Billion

119 点作者 mighty-fine将近 6 年前

12 条评论

killjoywashere将近 6 年前
Yep, if we really want to cure cancer, we need to go back into the tissue archives and study every single cancer that&#x27;s ever been diagnosed, at the molecular level, to start getting our heads around what really happened to all those people. 10 million people a year. Every year. For a the last 6-7 decades of chemotherapy.<p>Meanwhile, there&#x27;s this perverse medicolegal incentive to retain the excised tissue samples for the minimum necessary period of time, which is 10 years for US laboratories accredited by the College of American Pathologists.<p>You heard it right, the lawyers won. We spend medical administration time filling out medical administrative paperwork to spend medical care dollars burning most of the cure to cancer. Every year.
评论 #20521461 未加载
评论 #20522082 未加载
评论 #20524296 未加载
评论 #20521078 未加载
评论 #20521431 未加载
Roritharr将近 6 年前
Ironically, living in Germany makes me scared that I won&#x27;t be able to pay for a therapy by someone like Dr. Nagourney as our governmental health insurance providers are very eccentric when it comes to paying for treatments.<p>That combined with my high tax-rate and only slightly above average salary means I won&#x27;t be able to save enough money to afford it to send a loved one to him when it becomes necessary. That is crazy scary to me.<p>A programmer from close to my area had to publicly raise funds (~350k iirc) to send his 2 year old son to the US for a surgery that saved his life, but which no hospital in Germany dared to perform.[1]<p>[1] <a href="https:&#x2F;&#x2F;www.facebook.com&#x2F;hilf.david&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.facebook.com&#x2F;hilf.david&#x2F;</a>
评论 #20523946 未加载
1e-9将近 6 年前
Although there tends to be great molecular diversity in each person&#x27;s cancer, there are still avenues of genetic commonality that can be pursued. For example, the tumor suppression gene TP53 is mutated in a high percentage of cancer cases. If this mutation can be reliably repaired, our ability to treat a number of cancers could be significantly improved. There are recent results suggesting that this may indeed soon be the case (for example, treatment with APR-246).
signal_space将近 6 年前
Many cancers are heterogeneous. Once a malignant community forms the established organized population deteriorates into chaotic competition.
评论 #20521180 未加载
narrator将近 6 年前
The book &quot;Tripping over the truth&quot; is a great history of the failure of the genetic mutation theory of cancer to cure cancer. It argues that it&#x27;s a dead end and we should go back to exploring Otto Warburg&#x27;s metabolic theories.
评论 #20521132 未加载
评论 #20521605 未加载
评论 #20521072 未加载
leafeewick将近 6 年前
Would open sourcing all cancer research and allowing anyone to contribute and share in the open source community... would that assist in potentially finding a cure&#x2F;treatment for various cancers or would the profit motive be required for these research to be successful?
评论 #20521724 未加载
评论 #20522926 未加载
评论 #20525882 未加载
abrax3141将近 6 年前
<a href="https:&#x2F;&#x2F;mobile.twitter.com&#x2F;AmandaHaddock&#x2F;status&#x2F;922493664856760320&#x2F;photo&#x2F;1" rel="nofollow">https:&#x2F;&#x2F;mobile.twitter.com&#x2F;AmandaHaddock&#x2F;status&#x2F;922493664856...</a>
neonate将近 6 年前
<a href="http:&#x2F;&#x2F;archive.is&#x2F;VESVr" rel="nofollow">http:&#x2F;&#x2F;archive.is&#x2F;VESVr</a>
benkarst将近 6 年前
Paywall :&#x2F;
droithomme将近 6 年前
<i>&gt; Since there are some 1,000 cancer-related genes and each cancer requires up to three distinct gene alterations to succeed, every cancer patient is literally one in a billion.</i><p>Errors in his math:<p>- not every combination of any of the 3 genes (1000<i>999</i>998 = &quot;1 billion&quot; ordered combinations) causes cancer<p>- the order doesn&#x27;t matter<p>- the occurrence rates of each mutation are not the same and don&#x27;t appear in the same rate among various populations<p>Thus, the number of kinds is much smaller than 1 billion, and many people do have the same type genetically.
rolltiide将近 6 年前
Holistic practitioners should all be studying machine learning.<p>They were right about the problem of not having individualized medicine, way off with the solution. Now they can win with data
coding123将近 6 年前
If we really want to cure cancer we should stop polluting our air, water and food. And even if we can&#x27;t stop we need to find ways to disincentivize making products that require our air and water to be polluted. For food:<p><a href="https:&#x2F;&#x2F;www.basicknowledge101.com&#x2F;subjects&#x2F;verticalfarming.html" rel="nofollow">https:&#x2F;&#x2F;www.basicknowledge101.com&#x2F;subjects&#x2F;verticalfarming.h...</a>
评论 #20522502 未加载
评论 #20522548 未加载
评论 #20522210 未加载
评论 #20522460 未加载