I personally try not to tweet in the half hour before I go to sleep, as I find otherwise that I get too anxious wondering what the response will be to my tweet. I once tweeted something that was seen as offensive on a corporate Twitter account, and ever since then, I've not felt entirely comfortable tweeting something and knowing for sure that it won't be taken the wrong way. At least if I am awake, I can take appropriate action (clarification or apologizing) if necessary.<p>It is true that I miss out on some of the interaction by doing much of my tweeting during the Australia-is-awake time of day. Most of the time, I'm okay with that. If I'm very keen on an international audience, I will tweet it twice or tweet it early morning here (afternoon in the US). But I make sure to always be awake when I do that. :)