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Relationship between the ABO Blood Group and the Covid-19 Susceptibility

147 点作者 car大约 5 年前

14 条评论

Amorymeltzer大约 5 年前
Some quick points:<p>- Reported odds ratios[0] of 1.2 for A and 0.67 for O.<p>- This is a preprint, so it has not been peer reviewed.<p>- They compared blood type of patients with that of the general population in the region.<p>- Data is from 2,173 patients at three hospitals. The data varied between them, but Wuhan had the overwhelming majority (1,775, or 81%) of cases.<p>- Since these are all patients, they presumably are weighted toward the more extreme responses. There were minimal age and gender differences, though.<p>- A similar response for type O was apparently reported for SARS.<p>0: <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Odds_ratio" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Odds_ratio</a>
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Taniwha大约 5 年前
Because this is the next thing you&#x27;re going look up:<p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Blood_type_distribution_by_country" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Blood_type_distribution_by_cou...</a>
jakozaur大约 5 年前
Not as dramatic difference as the title suggests... Pulling numbers from the article.<p>3694 Control (Wuhan area)<p>A: 1188 (32.16%)<p>B: 920 (24.90%)<p>AB: 336 (9.10%)<p>O: 1250 (33.84%)<p>COVID-19 1888 patients<p>A: 715 (37.87%)<p>B: 494 (26.17%)<p>AB: 193 (10.22%)<p>O: 486 (25.74%)<p>The difference may be related to triaging criteria. E.g. different ethnic groups overrepresented in given hospital.
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umut大约 5 年前
This has no more value than being a &quot;fun fact&quot; (sorry for the word &#x27;fun&#x27; in the context of a pandemic and death numbers).. a) it is something you don&#x27;t have any control b) the diff (odds, bayes factor or any similar definition) is not that great to have an effect on public policy (something like, let&#x27;s focus our resources on region A, since region B has less risk kind of change)<p>So, let&#x27;s all enjoy this study as food for our curiosity, and move on with all the usual measures of social distancing, extra hygiene control and all.. Especially dangerous, if even one crazy person goes out because he has a certain blood type and helps the disease spread
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necovek大约 5 年前
Assuming the equal distribution of homo- and heterozygotes, it looks like the numbers (A&#x2F;AB +20%, B +3%, 0 -33%) <i>suggest</i> the following:<p>• 00 (homozygote 0, but that&#x27;s the only way someone is a 0) is at -33% &quot;chance&quot; of catching SARS-Cov-2<p>• B0 (heterozygote B) is at -10%<p>• BB (homozygote B) is at +5%<p>• AB (well, heterozygote, obviously) is at +20%<p>• A0 (heterozygote A) is at &lt;17%<p>• AA (homozygote A) is at ~33%<p>Basically, the hypothesis would be that presence of an A allele contributes significantly to increased risk (~17%), B is mostly neutral (+1-2%), a 0 allele contributes to decreased risk (-17%).<p>Considering the distribution in healthy individuals (I haven&#x27;t run the numbers but only used roughly 30% for each group except AB which is at 10% — I&#x27;ve only done the math in my head so I am way more off than that, and it would be quite unlikely for the effect to be so linear as my breakdown above suggests) from the study, everything roughly lines up.<p>It would be interesting if a study could confirm that, but they&#x27;d need parents blood types for every individual to be able to get that.<p>I&#x27;ve seen mention of open data sets that include research articles, but is there any data set to look at? It would be quite interesting since the distribution of blood types supposedly differs strongly among &quot;ethnicities&quot; if <a href="https:&#x2F;&#x2F;www.livescience.com&#x2F;36559-common-blood-type-donation.html" rel="nofollow">https:&#x2F;&#x2F;www.livescience.com&#x2F;36559-common-blood-type-donation...</a> is to be trusted — their &quot;Asian&quot; number for AB is also at 7% compared to 9% in their &quot;health population&quot; number.<p>If there was data just documenting whatever findings there are for patients, it would help in independent &quot;researchers&quot; find correlations that might not be obvious to others.
shekharshan大约 5 年前
I am a little rusty on my probability basics now but I was trying to remember how one would go about answering the following question regarding Wuhan numbers cited in this study:<p>&quot;Given a person has type A blood type, what is the probability of that person having covid19&quot;<p>I remember this being something like P(E1 intersection E2)&#x2F;P(E2) where E2 = event that a person has type A blood and E1 = event that the person has covid19.<p>In case of Wuhan 32.16% of the population has type A blood. So E2=0.3216. To get E1 we would need total infections&#x2F;total population for the city. We don&#x27;t have that number but is this thinking correct?
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hirenj大约 5 年前
I recommend reading the review below on known effects of blood groups on infection. Not super surprising in that blood group may have general effects. I can&#x27;t think how this would work mechanistically without knowing the glycans on ACE2&#x2F;TRMPSS2 or the spike, and if they carry antigen (I would expect not).<p><a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;m&#x2F;pubmed&#x2F;26085552" rel="nofollow">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;m&#x2F;pubmed&#x2F;26085552</a>
mrfusion大约 5 年前
How can blood type matter? What’s the mechanism of action?
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sdiq大约 5 年前
Slight nitpick: I find the use of &#x27;normal people&#x27; in the article a bit distracting. I appreciate the fact that the authors are not native English speakers but using &#x27;the general population&#x27; was more appropriate here. However, being a blood type &#x27;O&#x27;, I am not sure whether this consoles me.
outlace大约 5 年前
Assuming this result holds... Perhaps anti-A antibodies that may be produced by non-A blood types have some cross-reactivity with the virus?
Vysero大约 5 年前
Well.. I don&#x27;t know what blood type I am but it is somehow comforting to know that there are at least some people out there who have a better chance at not getting sick.
david_draco大约 5 年前
Odds ratios between 0.5 and 1.5 are not exactly considered strong evidence. <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Bayes_factor#Interpretation" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Bayes_factor#Interpretation</a>
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mikorym大约 5 年前
By the way (and not flamebaiting here) this is one of the reasons why &quot;this is natural selection&quot; is the phrase that makes me the most angry in all of this. Death by flu is selection for random shit that cause you to be better off <i>against only one thing and that is: that exact desease causing strain</i>.<p>The worst thing about Covid 19 to me is how it selects against old people, and even worse: Friendly, sociable old people.
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sub7大约 5 年前
This has been circulating for a few days now. It&#x27;s bogus.<p>There is absolutely 0 peer reviewed papers or double blind controlled studies that prove this.
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