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Direct evidence for T-cell immunity as a factor behind Covid-19 heterogeneity

177 点作者 kaonwarb将近 5 年前

9 条评论

trenchgun将近 5 年前
Misleading headline. From the article:<p>&gt; Based on these data, it is plausible to hypothesize that pre-existing cross-reactive HCoV CD4+ T cell memory in some donors could be a contributing factor to variations in COVID-19 patient disease outcomes, but this is at present highly speculative<p>Also I recommend to read this: <a href="https:&#x2F;&#x2F;www.theatlantic.com&#x2F;health&#x2F;archive&#x2F;2020&#x2F;08&#x2F;covid-19-immunity-is-the-pandemics-central-mystery&#x2F;614956&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.theatlantic.com&#x2F;health&#x2F;archive&#x2F;2020&#x2F;08&#x2F;covid-19-...</a>
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nostromo将近 5 年前
&gt; We demonstrate a range of pre-existing memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63, or HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in COVID-19 disease.<p>Could we just start deliberately spreading these weaker cold viruses then?
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phendrenad2将近 5 年前
So basically this is saying that previous exposure to various versions of the common cold can lead to some covid resistance?
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LordHumungous将近 5 年前
How can I get infected with one of those other Coronaviruses?
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avancemos将近 5 年前
From the abstract: &quot;We demonstrate a range of pre-existing memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63, or HCoV-HKU1.&quot;<p>1. Populations may naturally have a head start towards herd immunity from COVID. 2. Sweden could be really close in that regard; their current super low daily mortality and declining cases may point towards herd immunity.
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DangerousPie将近 5 年前
What&#x27;s up with the editorialised title, which clearly overstates the conclusions of the paper?
peter_retief将近 5 年前
Does this imply that the COVID-19 virus will morph into the common cold virus?
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armada651将近 5 年前
This would also explain why the anti-body tests have proved so unreliable. A lot of people already have reactive anti-bodies without being exposed.
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known将近 5 年前
I believe Antibody is better than Vaccine <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Antibody#&#x2F;media&#x2F;File:Antibody_Opsonization.svg" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Antibody#&#x2F;media&#x2F;File:Antibody_...</a>