Just this week, I uninstalled all my desktop mail clients: no more Thunderbird, MailMate, or eM Client.<p>Fastmail's web app feels faster, uses fewer resources, and has the same UI on all of my computers.<p>Instead of redirecting all other accounts into Fastmail, it has a simple UI to setup fetching-from and sending-as from other mail providers, and with using my own domain, it does not feel like a lock-in.