I think a lot more has to happen for the mouse to die. It might get less popular in the computing mainstream, if the new-fangled devices really take over (i.e. no more PC as a "hub"), but that just means we're back to the "workstation" days, and the expert users will still use that (+ keyboard shortcuts etc.).<p>The infamous "gorilla arm" has been mentioned here already. For a 8+ hours computing device, a bit more has to change than just tablets and Windows 8. We'd need some kind of super-ergonomic version of the Tron CEO desk.<p>NB: For those professionals who aren't using their mouse due to super-keyboard-efficiency (or possible pseudo-efficiency), it might as well replace it for the few times they'll use it. Whether the occasional moment of direct manipulation is handled by a mouse, trackball, trackpad, IBM nipple or touchscreen isn't that important.