There has been a strong correlation between the build up of amyloid plaques and degenerative brain diseases. I think the expectation has always been that this is a build up over time, and that one all-nighter or a few isn't harmful. Like eating fries, your body will repair itself as long as you don't make it a habit.<p>This study suggests that the brain does not remove these built up paque over a 4 week period. I'd be very interested to see if the researchers are able to do a further follow-up study, but this is very damning evidence of the importance of quality sleep...always!<p>My startup (<a href="https://soundmind.co" rel="nofollow">https://soundmind.co</a>) is working on using sound to improve sleep quality, and our DeepWave stimulation is specifically targeting the processes which clear the amyloid plaques discussed in the paper. There is great research regarding improving the capabilities of the brain to clear plaque in a reduced time frame by increasing the power and number of waves in a slow-wave oscillation.<p>I had been under the assumption that this meant we would be able to repair previous damage to a certain percent. Unfortunately, this appears not to be the case.<p>As a life-long insomniac who witnessed an uncle die from Alzheimer's, I'm very concerned of the effects.<p>Please take care of your sleep. I'm working to help you, but until we're able to do it, and prove that we can do it, just don't damage yourself.