> The secondary circuitry produces the four output voltages: 5 volts, 12 volts, -12 volts, and 3.3 volts. [...] The power supply also provides a negative voltage output (-12 V). This voltage is mostly obsolete, but was used to power serial ports and PCI slots.<p>And even older PC power supplies also provided a -5V voltage, the corresponding pin on the ATX connector is now (according to Wikipedia) a reserved pin.<p>This progression also shows in the expansion slot standards: the ISA slot had pins for -5V and -12V; the PCI slot removed the -5V pin; and the PCIe slot finally removed the -12V pin. That is, a motherboard without any ISA or PCI slot, and without a RS232 socket or header, has no use for the -12V voltage.<p>And there's already a newer power supply standard, called ATX12VO, which simplifies the power supply by providing only 12V (and a separate standby 12V). There's already at least one motherboard built for that standard: <a href="https://www.anandtech.com/show/15763/first-atx12vo-consumer-motherboard-the-asrock-z490-phantom-gaming-4sr" rel="nofollow">https://www.anandtech.com/show/15763/first-atx12vo-consumer-...</a>