Brain imaging before and after Covid-19 in UK Biobank

I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?

Looking at the scatter plot [1] from their most statistically significant finding (parahippocampal gray matter change), the effect size is tiny, and the variance is large. Nearly half the case participants had <i>more</i> gray matter after getting covid.<p>[1] <a href="https:&#x2F;&#x2F;i.ibb.co&#x2F;5YcxJHH&#x2F;EDB20654-900-A-427-C-8063-B5-FA667-A0-D79.jpg" rel="nofollow">https:&#x2F;&#x2F;i.ibb.co&#x2F;5YcxJHH&#x2F;EDB20654-900-A-427-C-8063-B5-FA667-...</a>

FWIW this thread was a good read: <a href="https:&#x2F;&#x2F;mobile.twitter.com&#x2F;skepticalzebra&#x2F;status&#x2F;1405899724117393411" rel="nofollow">https:&#x2F;&#x2F;mobile.twitter.com&#x2F;skepticalzebra&#x2F;status&#x2F;14058997241...</a><p>Apparently there are previous studies (pre-covid Era) that found similar changes in the brain associated with loss of smell.<p>Quoting:<p>&gt; What if I told you there was also an illness in which:<p>&gt; &quot;grey matter reduction was observed in the gyrus rectus, orbitofrontal cortex, thalamus, and the insula&quot;<p>&gt; This is taken from a study on Chronic rhinosinusitis with olfactory loss

This sounds alarming:<p>&gt; There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism.<p>This doesn&#x27;t:<p>&gt; We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison<p>What are the quantitative findings of &quot;loss of grey matter&quot;?<p>What mechanism&#x2F;s are suspected that might be specific to COVID19?

Stress reduces brain volume in similar areas, this effect could just be that people got extremely stressed out from having caught the pandemic virus. I&#x27;d like to see these studies take stress into account before I believe that covid hurts your brain.<p><a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC4677120&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC4677120&#x2F;</a>

I&#x27;m pretty sure we had covid in March 2020, and my wife has since then been extremely tired - like needs a 2 hour nap every afternoon and in bed by 8pm - and brain foggy. She&#x27;s had concussions in the past, so I haven&#x27;t been sure when one brain fog ended and the other fog started, but I do wonder if it&#x27;s post-covid related. I just don&#x27;t know what to do about it though. Doctors are finding nothing.

Note there is a corrected version of this paper:<p><a href="https:&#x2F;&#x2F;www.medrxiv.org&#x2F;content&#x2F;10.1101&#x2F;2021.06.11.21258690v2" rel="nofollow">https:&#x2F;&#x2F;www.medrxiv.org&#x2F;content&#x2F;10.1101&#x2F;2021.06.11.21258690v...</a><p>Which includes 3 diabetes patients for comparison of hospitalised and non-hospitalised in Table figure 3.

If person is suffering from ischemia&#x2F;hypoxia due to covid, that could be the way to lose gray matter.