I do not understand what the 5 year plan is. Even less what the 50 year plan is.<p>On one hand:<p>We are blessed to have access to mass genetic vector vaccines. Genetic vector vaccines are amazing at shaving off the sharp edge of the pandemic. Even after effectiveness drops against infection, they are still amazing at preventing severe infections. "VE for severe disease is *still high* after 6 months - 94% for ages 40-59, 86% for 60+.", <a href="https://twitter.com/_lewisy/status/1430291421085552641" rel="nofollow">https://twitter.com/_lewisy/status/1430291421085552641</a>.<p>On the other hand:<p>* There is no path to ZeroCovid due to high airborne infectiousness, leaky genetic vector vaccines, immense human global population and reported animal reservoirs.<p>* The genetic vector vaccine effectiveness appears to diminish after ~6 months, thus booster shots.<p>* Leaky genetic vector vaccines are bound to give raise to vaccine-resistant variants, just like incomplete antibiotic courses give raise to antibiotic-resistant bacteria.<p>* Every time a new genetic vector vaccine variant is developed, it takes a long time to pass the FDA tests and even then it carries a tiny, but not zero, risk of ADE. OK, we'll roll the Russian Roulette once. But we can't forever play Russian Roulette with a mutating virus.