L-arginine in severe Covid-19 decreases the length of hospitalization

Just wanted to say that this seems like really good data. Pre-registered RCT with a large n and a very significant measured effect.<p>I kind of wonder how necessary&#x2F;effective this treatment would be in people who are already enough protein, they didn&#x27;t include info on the diets of the patients involved.

3.2g of arginine in a day doesn&#x27;t sound like a lot. There&#x27;s around 2g in most meat&#x2F;protein servings, and 1g on each egg yolk[0]. I wonder how much of the study outcome is just the result of changing dietary habits of the patients.<p>[0] <a href="http:&#x2F;&#x2F;www.dietandfitnesstoday.com&#x2F;arginine.php" rel="nofollow">http:&#x2F;&#x2F;www.dietandfitnesstoday.com&#x2F;arginine.php</a>

This seems consistent with the fact that Arginine is a conditionally essential amino acid. Our body can naturally make its own Arginine most of the time. When tissues are under increased stress (wound healing is a good example), Arginine becomes essential (the healing tissue can&#x27;t make enough on its own and needs extra exogenous Arginine).<p>I&#x27;d be curious to see whether this effect is specific to COVID or if Arginine is also beneficial in non-COVID ARDS&#x2F;Pneumonia.

Cited from the study: &quot;20 days after randomization we failed to detect any significant difference in the primary outcome between the study arms&quot; (p4). The fact that it has no difference in primary outcome (removal of respiratory support) makes me very skeptical of its secondary outcome claims (time to discharge).

This adds to the pile of evidence suggesting that most people with severe COVID symptoms are in that position due to their own health and diet choices. I am thinking of the studies showing the concurrence of obesity or vitamin D deficiency with COVID hospitalization.

For those without access: <a href="https:&#x2F;&#x2F;www.thelancet.com&#x2F;pdfs&#x2F;journals&#x2F;eclinm&#x2F;PIIS2589-5370(21)00405-3.pdf" rel="nofollow">https:&#x2F;&#x2F;www.thelancet.com&#x2F;pdfs&#x2F;journals&#x2F;eclinm&#x2F;PIIS2589-5370...</a>

Isn’t it easier to get vaxxed and reduce your chance of cytokine storm than to hope that there are existing compounds that can help repair lung damage once it’s already occurring? There are already immunosuppressants that are cheap and widely available that reduce damage, and the search is on for things that inhibit viral replication. I think there is also research for universal antibodies that attack regions that are rarely mutated.<p>Would be great if such last possibility treatments work as patients are usually post COVID by the time the lungs are shot. The course of other diseases would profit from lung repair, possibly even smoking damage.

Arginine will boost your Nitric Oxide (NO) production abilities. It&#x27;s often used as a simple ED treatment, for example. NO is a vasodilator.<p>This could align to recent NO-based nasal treatments against COVID.

This is yet another piece of compelling evidence showing that nutraceuticals can significantly reduce recovery time and improve health outcomes.<p>Combined with <i>early</i> treatment using widely available medicines, it’s clear we have a variety of tools at our disposal to mitigate this pandemic.<p>Unfortunately many people are unaware of the evidence supporting these types of treatments, partly because they receive such little attention in mass media.<p>As usual I’m ready for the downvotes - for some reason people here think this information is contentious or disagreeable.

&quot;a significant difference was not detected 20 days after randomization, most likely because most of the participants in the L-arginine arm had been already discharged from the hospital by this time&quot;

If memory serves, isn&#x27;t L-arganine a treatment for herpes as well?