I used to work in emergency medicine as a paramedic. A far cry from an MD for sure, but here's my two cents: Unless they were already in decline, I never suspected Sepsis based solely on vitals. It was usually more of a gut feel thing. It can present with weird symptoms, like unexplained joint pain in multiple joints and things like that. I think that two key tells are patient history and patient cognition relative to baseline. My favorite question to ask family is: "How are they normally?" It's hard to measure these things with vitals so the AI doesn't have the right data going in, IMO. But, take all this with a grain of salt as I am deeply uninformed on the subject.