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Autism affects the microbiome, not the other way around

93 点作者 wyrm超过 3 年前

13 条评论

armchairhacker超过 3 年前
&gt; So this study concludes that kids with ASD have reduced dietary diversity because of their behaviors, and this alters the taxonomic composition of their microbiome<p>This sounds reasonable. Anecdotally autism and OCD can cause strange eating habits.
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acd超过 3 年前
Try hacking Microbiome with different kinds of Probiotics. The gut brain axis is two way. Thus you may be able to lessen autism spectrum dissorder symptoms via Probiotics.<p>Research articles <a href="https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;28686541&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;28686541&#x2F;</a><p><a href="https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;34062986&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;34062986&#x2F;</a><p><a href="https:&#x2F;&#x2F;www.frontiersin.org&#x2F;articles&#x2F;10.3389&#x2F;fendo.2019.00508&#x2F;full" rel="nofollow">https:&#x2F;&#x2F;www.frontiersin.org&#x2F;articles&#x2F;10.3389&#x2F;fendo.2019.0050...</a>
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peter303超过 3 年前
This talk at MIT a few days ago measured nervous system disruption in rident guts with autism analogs.<p><a href="http:&#x2F;&#x2F;calendar.mit.edu&#x2F;event&#x2F;exploring_gut-brain_signaling_in_autism#.YZlNmy1Haf0" rel="nofollow">http:&#x2F;&#x2F;calendar.mit.edu&#x2F;event&#x2F;exploring_gut-brain_signaling_...</a><p>The conclusion is both the gut and brain may be affected by whatever causes autism. But the study didnt attempt to establish whether the gut affected the brain, or the brain affected the gut, or were they simultaneous.
lthornberry超过 3 年前
This is an interesting study, but it’s far from the conclusive answer to the question of how the gut microbiome relates to neurological conditions. Given the heterogeneity and complex etiology of autism, a study of this size is not sufficiently powered to pick up all plausible correlations. If there is a causative connection between the microbiome and autism, it’s likely only true of a subset (perhaps a small one) of autistic people.
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strogonoff超过 3 年前
Would this be the beginning of a trend? I have an intuition that reversing the causal relationship between high-level (psychology, mind, behaviors) and low-level (physiology, disease manifestations) matters can significantly advance medicine.
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podgaj超过 3 年前
It is also probable that both autism and altered micro biome are co-arising conditions with an underlying genetic link. Many genes implicated in ASD are also genes that can effect the mucrobiome.<p>If you want me to explain this more let me kmow.
eluusive超过 3 年前
I doubt that. It&#x27;s likely both; as with most things in nature.
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Jeff_Brown超过 3 年前
While demonstrating that autism influence the microbiome seems not especially tricky, demonstrating that the microbiome does not also influence autism seems next to impossible.
DoreenMichele超过 3 年前
I think obviously it&#x27;s a two-way street. There are many factors here. They seem to be oversimplifying the issue, which is perhaps understandable but will lead to erroneous conclusions rooted in bad mental models.
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im3w1l超过 3 年前
I remember when I heard people saying a better gut flora could treat autism alarm bells started ringing about microbiome stuff being way overhyped for me.<p>This causal direction makes sense though.
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supperburg超过 3 年前
The micro biome is lauded everywhere and considered as the last great frontier of medicine which will solve all human ailments. There is barely any disease that is not regarded as being potentially caused by the micro biome. It’s all complete horse shit.
zackmorris超过 3 年前
After going through the worst burnout of my life from 2018 to 2020, I have proof in my own life that diet and digestive issues are hugely correlated with cognition and mood.<p>Personally, I don&#x27;t expect these kinds of studies to find a smoking gun. The chemical interactions between foods and the immune system are far too complex to be understood at this time. The immune system is the second most complex biological system after the brain. But we can still get clues. I highly recommend the everlywell comprehensive test (no affiliation) of 200+ foods, which I took that confirmed my suspicions about certain foods:<p><a href="https:&#x2F;&#x2F;www.everlywell.com&#x2F;products&#x2F;food-sensitivity-comprehensive-test&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.everlywell.com&#x2F;products&#x2F;food-sensitivity-compreh...</a><p>There&#x27;s also a regular test of 100 foods for about half that price. And yes, these tests have their flaws, but can still inform us.<p>I&#x27;ve also been taking ashwagandha for a few months for ADHD symptoms (still undiagnosed, but I&#x27;ll get to it, I swear!) after hearing good things about it online. I&#x27;m an INFP with 78% on intuition, so I&#x27;m somewhat cursed with knowing the solutions to problems before people finish explaining them to me. Which is great for programming, but debilitating when living in a sick society healing from recent events in these times. My &quot;deficits&quot; (should really be differences) are around dissociation because it&#x27;s too easy for me to slip down interesting rabbit holes. Living and working in the malignant mundanity of The Matrix while knowing a better world is just beyond our reach due to dogma, takes everything I got, every single day.<p>Attempting to keep this brief, I believe that ashwagandha may desensitize the immune system to nightshades, which are pretty much all of the fun foods. I also suspect that it raises the proportion of good bacteria in our gut that live on roots. Humans evolved as scavengers eating icky things, but our surroundings and food are too sanitized today, so autoimmune issues and inflammation will eventually come to dominate our medical system.<p>Which was the plot of a 1990s sci fi series called Earth 2, where a billionaire&#x27;s kid gets &quot;the syndrome&quot; from living in too sterile of an environment:<p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Earth_2_(TV_series)" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Earth_2_(TV_series)</a><p>So people have known about this stuff for a long time.<p>For anyone curious, the way I got out of burnout (severe anxiety, I learned) was by completely shutting down for a few months and taking care of the chores I had put off for years&#x2F;decades. I had to relearn how to break overwhelming tasks down into simpler steps on my todo list and just do what I could each day, even if it was only one thing or getting out of bed. But more importantly, service. I let my ego finally die and gave myself over to helping others. That was the missing piece we don&#x27;t hear about in a capitalistic&#x2F;patriarchal &quot;me&quot; culture.<p>Kids are very bright, often just as capable as you and me (you remember) but forced to endure eons of slow growth before they are free. I think we&#x27;ll find that most developmental &quot;disorders&quot; are clues as to what&#x27;s wrong with our society, and that as we all heal and ascend, they&#x27;ll begin to subside.
lightweb超过 3 年前
There&#x27;s a lot of research that contradicts these notions, and also practical advice on how to remedy through food choices, if one is inclined to look into it. As with anything, it&#x27;s a controversial subject, probably due to the severity of autism and the real difficulties of changing one&#x27;s diet radically.<p><a href="http:&#x2F;&#x2F;www.doctor-natasha.com&#x2F;gaps-book.php" rel="nofollow">http:&#x2F;&#x2F;www.doctor-natasha.com&#x2F;gaps-book.php</a><p><a href="https:&#x2F;&#x2F;www.medicalnewstoday.com&#x2F;articles&#x2F;325046" rel="nofollow">https:&#x2F;&#x2F;www.medicalnewstoday.com&#x2F;articles&#x2F;325046</a><p><a href="https:&#x2F;&#x2F;www.goodreads.com&#x2F;en&#x2F;book&#x2F;show&#x2F;978904.Gut_and_Psychology_Syndrome" rel="nofollow">https:&#x2F;&#x2F;www.goodreads.com&#x2F;en&#x2F;book&#x2F;show&#x2F;978904.Gut_and_Psycho...</a>
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