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‘Dancing molecules’ successfully repair severe spinal cord injuries

387 点作者 wasi0013超过 3 年前

14 条评论

Pasorrijer超过 3 年前
I truly, truly hope this works as described, even partially, on humans. It is so frustrating to see someone who would be able to walk if only the signal could get to their lower extremities.<p>My grandfather is a paraplegic, and man how much I hope this isn&#x27;t just faery dust.
rocqua超过 3 年前
Based on this stimulating Axon growth, it sounds like it might help to repair the damage caused by MS. That would be amazing news. Not a cure per se, but a way to actually treat symptoms rather than just surpressing. Worryingly, they mention a few neurodegenerative diseases but not MS.
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dpcx超过 3 年前
Do I want to know how they get mice with severe spinal cord injuries to test on? I&#x27;m guessing it&#x27;s exactly what I think it is, but I&#x27;m wondering if there&#x27;s another way that it happens.
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ghastmaster超过 3 年前
&gt; The therapy also induces myelin to rebuild around axons and reduces glial scarring, which acts as a physical barrier that prevents the spinal cord from healing<p>This gives the impression that this would need to be administered before any scaring takes place. It is probably not a remedy for people with old injuries.
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gibbonsrcool超过 3 年前
I&#x27;ve always wondered... and so far have been unable to Google this: Does the non-nucleus part of a severed nerve cell die? If so, that would mean we only have a small window to &quot;rejoin&quot; severed CNS nerve cells, right? Nerve cells can be very long, I think up to a meter. I&#x27;d assume this includes spinal nerve cells of the CNS, which don&#x27;t regrow. If the cells are severed, like in a spinal injury, that means there&#x27;s a half-cell fragment with a nucleus, and the other half is the axon that&#x27;s been cut away without a nucleus. Wouldn&#x27;t the fragment without a nucleus shrivel up and die? That would be my intuition because I&#x27;d assume the nucleus is necessary to keep a cell alive.
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markdeloura超过 3 年前
I find myself wondering whether a useful testing step between mice and people might be the community of small dogs with IVDD. French bulldogs, dachshunds, and corgis seem particularly susceptible and many of them wind up with rear paralysis. <a href="https:&#x2F;&#x2F;www.thedogsdown.com&#x2F;how-can-ivdd-cause-paralysis&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.thedogsdown.com&#x2F;how-can-ivdd-cause-paralysis&#x2F;</a>
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sidlls超过 3 年前
The last section about generalizing the treatment is a bit underwhelming. Have they seen any evidence it can be used outside this sort of repair? What about for neuropathies, as from diabetes or surgeries? Stroke? Other dysfunctions (e.g. erectile&#x2F;genital) having nervous system issues as a contributing factor?<p>Any treatment &quot;might&quot; have more general applicability--but surely there is some specific direction&#x2F;class of these conditions that are indicated to be more appropriate to apply the treatment to than others. I wish they&#x27;d gone in more depth here.
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iandanforth超过 3 年前
IN MICE.<p>Seriously, mice are <i>really really</i> good at healing these injuries. You can find dozens of &#x27;heals spinal cord injuries IN MICE&#x27; articles.
bilekas超过 3 年前
These kind of studies and experiments always sound so amazing, but how long would something like this take to be applicable for at least human trials ?<p>I understand there are so many precautions to take etc, but is there any kind of &#x27;complete consent&#x27; one could sign to jump start stuff like that ?
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ChuckMcM超过 3 年前
Nice, I&#x27;ve added a link to my calendar to check up on this work a year from now.<p>As described, it seems as though it would work just as well for traumatic brain injury as well. Either way it would be a huge boost in the quality of life for a lot of people.
Karunamon超过 3 年前
I wonder if this would work with something like Guillaine-Barre syndrome (to wit, an autoimmune disease where the body attacks its own nerves, causing demyelination)
stretchwithme超过 3 年前
Fingers crossed.<p>I suspect Christopher Reeve had a hand in this somehow. Creating awareness and motivation to work on this.
ekianjo超过 3 年前
Again mice models...
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0x0nyandesu超过 3 年前
Recently every thread on HN about life and death has been devolving into a debate with people who insist that these things need to be addressed in the comments and those that simply don&#x27;t care. It&#x27;s honestly exhausting.<p>It&#x27;s sort of like making food and having someone at the table try to discuss the morality of the meat you&#x27;re using.... Except it&#x27;s every. single. time.<p>Lab mice are killed off everyday after experiments end even if there&#x27;s nothing wrong with them. Excuse me if I don&#x27;t lose any sleep over this experiment.
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