I switched to Colemak 4 years ago or so, and I think it is one of the best investments of my time ever made. Yes, you will feel similar to that feeling you get when you write with your left hand (something like, why tf I'm doing this, if i'm perfectly capable of living my life as I have been doing before), but it is a skill that will benefit you all your life and I would recommend you to do so.<p>Still, it is not perfect. The pinky getting tired is something that happens, but it is still so much better than QWERTY. I don't think I will try that QWYRFM layout, as I haven't felt big pain since switching (before switching I felt some pain, but after, I slightly feel something, but after a lot of effort, and not enough to feel worried). And I think if I start feeling something to worry, there are some things I could do before, like using a split keyboard, or optimizing the desk height, before switching to another layout.<p>Again, try Colemak (or if you want to try any other layout, welcome). It will do good for you.