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Nuclear pore complex by integrative cryo-EM and AlphaFold

1 点作者 DantesKite将近 3 年前

1 comment

DantesKite将近 3 年前
For context, the nuclear pore complex is one of the largest structures inside a human cell. Using AlphFold and some special microscopy, researchers were able to simulate a model of the nuclear pore of an African Claw frog egg (the frog eggs are easier for researchers to &quot;see&quot; without much intervention and tend to contain many nuclear pore complexes per egg).<p>This is an important results since they&#x27;re a rather important structure and have been linked to a few diseases in humans, but because of their complexity, they&#x27;ve been difficult to model, despite some efforts over the past 20 years.<p>Now, for the first time, thanks to advances in machine learning, we know what they look like. At least in the frog version. And have a general approach for modelling protein structures in the future.<p>It&#x27;s a great day for science.