"As an experiment, I went through a list of holiday weekend sales, and opened all the sites. They all — all, 100% — interrupted my attempt to give them some money."<p>This is a good touchstone to use for "you've overoptimized your site, tone it back". I am also taken aback every time I'm on a site, I've got something in my shopping cart, I'm headed for the "check out" button, or I'm even <i>on the checkout page</i>, and some stupid interstitial pops up. Dude, I'm trying to enter my credit card information! Back off! Especially stupid for a "sign up for our newsletter" popup; we all know that unclicking the "yes, we can email you every 17 seconds from now until the heat death of the universe with valuable offers from 'our affiliates' which we define as 'anyone we share a species with'!" box on the checkout form is mandatory, and if we don't see it immediately we'd best go hunting for it. You've already default populating the checkbox to "yes" on this <i>very screen</i>, get out of the way!<p>Less unbelievably stupid, but related, is when I'm examining product X and just after I scroll down a bit to read more you pop up something related to... well... anything other than product X! I'm signalling interest in product X as hard as I can, and you've AB tested that this is a great time to jangle your keys over there instead? Your AB testing is stupid and can't possibly fail to be some stupid statistical fluke or other terrible error. What fisherman goes out on his boat, hooks a fish, and then rushes to throw another completely different lure out to the hooked fish and get them on that hook instead? This is another good touchstone for being "overoptimized".