Vaccine development against methamphetamine drug addiction [pdf] (2020)

There is a great TV series called Traffik (later adapted into a film) which makes the case that drug addiction primarily stemmed from social and not chemical causes... I wonder if that view is infact true. If it is, then I would think that meth users would just switch to another drug if meth were made ineffective.<p>Does anyone knowledgeable know where the evidence seems to point in terms of the root addiction being chemical vs. social (vs ...) based?

This is absolutely fascinating, but I&#x27;d say the title isn&#x27;t fully accurate. These vaccines seem to be entirely neutralizing methamphetamine in all it&#x27;s functions. Using alcohol as a metaphor, it&#x27;d be like you could drink as much as could fit in your stomach and just never get drunk.<p>So while yes, I can imagine it&#x27;d be useful in preventing addiction, does it really mean the same if you&#x27;re physically&#x2F;mentally incapable of feeling the effects of the substance to begin with?

Can someone summarize by what mechanism the immune system can somehow fight meth addiction?<p>I can&#x27;t see how those two biological worlds interact.

Vaccine to screw with your motivation system geee what could go wrong?

For better or worse, we&#x27;re entering a new era of human development if parents can choose to &#x27;immunize&#x27; their kids to addictive drugs. What a bizarre development.<p>Its even weirder when you imagine these future people would be able to take the drugs without suffering&#x2F;enjoying the effects. That would make for some odd&#x2F;dangerous social situations.

I wonder how how this impacts other forms of amphetamines?<p>From the perspective of a person that struggles with ADHD, I&#x27;d really hate to think that some overzealous parent immunizes their kid against medications that help them function in the world.

Can someone explain the use of the word &quot;vaccine&quot; here?<p>My layman&#x27;s understanding of medical industry is that a vaccine is only useful against a &quot;virus&quot;. Has the word &quot;vaccine&quot; turned into a generic word for &quot;medicine&quot; in many cases?<p>They state &quot;vaccine development strategies&quot; as their motivations, but seem to skip over the idea what the actual definition of a vaccine is, but then allude to it by stating &quot;drug-vaccine conjugation&quot; after already stating (as fact) there is such a thing as &quot;METH vaccine development strategies&quot;.<p>Maybe I am just too much an outsider, but the past 20 years I feel like a vaccine can cure more than it could in the past...

&gt; In the same study selectivity of MH6 antibodies to bind to AMP, METH, 4-methyl-N-methylcathinone (4-MMC), or methylenedioxy-methamphetamine (MDMA) were evaluated by equilibrium dialysis.<p>I&#x27;m glad that 4-MMC meets some studies. I believe this is a next-gen drug with cocaine-like effects and little or no contraindications.