Reddit's founder Alexis Ohanian was not technical at all, he just took care of PR/marketing.<p>Incidentally I graduated from the same high school as Dennis Crowley, from what I've gathered he was pseudo technical - he had the domain knowledge and had built products but hired others to build those particular products you named.
Mark Cuban wasn't very technical (although self-taught programmer) and had a multi-million and billion dollar exit before 2000.<p>The AirBnb founders are designers AFAIK. Jason Fried is non-technical (strong design and writing skills though), as well.