For what it's worth, just as an amateur chemist staring hard at the molecule, it looks like the ligand (the outer bit that plugs into receptor binding sites) consists of a monochlorinated benzene ring. Which would likely put this in the same drug class as <a href="https://en.wikipedia.org/wiki/Bromantane" rel="nofollow">https://en.wikipedia.org/wiki/Bromantane</a>, whose ligand is a <i>monobrominated</i> benzene ring — and which is also a "cognitive enhancer" nootropic with a thusfar not well understood mechanism-of-action.<p>The naive assumption some people make is that bromantane (and so probably also ISRIB) would have an at least partially similar MoA to amphetamine, given that amphetamine has a plain old benzene ring hanging off of one end of it; but IIRC that is incorrect, as, in amphetamine, the benzene is not the ligand — rather, the amide group on the other end is.