Considering the Western diet, human evolutionary history of constant near starvation, and how chemotherapy works, isn't cellular stress a near universal weakness of most neoplasmic cells?
This sounds very interesting. Being able to associate specific cancers with pathways worth dampening/shutting down may not just enable new medications but might allow us to leverage existing medications and engineer cocktails of medications for which we already know how they affect the cellular pathways.
If they think this will not have side affects in humans they are mistaken.<p>MTFHD2 is needed in our mitochondria and blocking it will be worse than using methotrexate. There will be such a huge build of of NAD in the mitochondria things will go haywire.<p>Maybe you all should stop eating so much folate so you do not get cancer in the first place:
<a href="https://bmjopen.bmj.com/content/2/1/e000653" rel="nofollow">https://bmjopen.bmj.com/content/2/1/e000653</a><p>And what is weird is that these same oncologist were telling my father to take folate when he was dying of cancer.