TE
科技回声
首页24小时热榜最新最佳问答展示工作
GitHubTwitter
首页

科技回声

基于 Next.js 构建的科技新闻平台,提供全球科技新闻和讨论内容。

GitHubTwitter

首页

首页最新最佳问答展示工作

资源链接

HackerNews API原版 HackerNewsNext.js

© 2025 科技回声. 版权所有。

An FDA-approved asthma drug has shown the ability to restore memories in mice

104 点作者 BoardsOfCanada超过 2 年前

13 条评论

58x14超过 2 年前
Whenever I read articles or studies about scientific approaches to &quot;restoring&quot; memories, particularly approaches involving pharmaceuticals, I instinctively assume there&#x27;s a significant metacognitive counterpart. Surely mental&#x2F;psychological techniques and external stimuli have an equal or greater impact on memory retrieval?<p>I have a bizarre personal anecdotal experience with spontaneous memory activation. I was leaving work one evening, and I&#x27;m recounting a dream from the night prior to a colleague as we left.<p>Suddenly, in what felt like an instant, I began to rapidly recall a chain of lucid dreams I&#x27;ve had. Dreams I hadn&#x27;t remembered in years. I remembered not only the dreams themselves, but my life&#x27;s circumstances when I had them. I describe this as a chain, but it felt to me more of a... portal. As if inside each of these dreams was a connection to the next.<p>I awkwardly paused, said a brief goodbye, and returned inside to look at myself in the mirror. My pupils were very dilated, and I felt like I was on psychedelics.<p>The strangest part is that this... connection has persisted. If I try to recall <i>any</i> of these dreams, including writing this comment, I&#x27;m unwillingly transported through these memories, and I have to consciously focus elsewhere.<p>No idea what to make of this, but it&#x27;s definitely interesting.
评论 #34756602 未加载
评论 #34756473 未加载
评论 #34756708 未加载
评论 #34757020 未加载
评论 #34769439 未加载
评论 #34757989 未加载
FollowingTheDao超过 2 年前
The Headline is misleading: &quot;Recovering object-location memories after sleep deprivation-induced amnesia&quot;<p>This is possibly only effective in stress induced amnesia.<p>This effect of Roflumilast has been known since 2015: <a href="https:&#x2F;&#x2F;www.sciencedirect.com&#x2F;science&#x2F;article&#x2F;abs&#x2F;pii&#x2F;S0014299914007468" rel="nofollow">https:&#x2F;&#x2F;www.sciencedirect.com&#x2F;science&#x2F;article&#x2F;abs&#x2F;pii&#x2F;S00142...</a><p>Roflumilast is a PDE4B and PDE4D inhibitor.<p>The enzyme, PDE4 (<a href="https:&#x2F;&#x2F;www.uniprot.org&#x2F;uniprotkb&#x2F;P27815&#x2F;entry" rel="nofollow">https:&#x2F;&#x2F;www.uniprot.org&#x2F;uniprotkb&#x2F;P27815&#x2F;entry</a>) uses Zinc and&#x2F;or Magnesium as a cofactor.<p>What is the function of PDE4? It metabolizes cAMP (3&#x27;,5&#x27;-cyclic AMP + H2O = AMP + H+) stimulated by Nitric Oxide which is responsible for LTP, or memory formation.<p><a href="http:&#x2F;&#x2F;learnmem.cshlp.org&#x2F;content&#x2F;13&#x2F;1&#x2F;35&#x2F;F7.expansion.html" rel="nofollow">http:&#x2F;&#x2F;learnmem.cshlp.org&#x2F;content&#x2F;13&#x2F;1&#x2F;35&#x2F;F7.expansion.html</a><p>This is what Viagra does as well but Roflumilast works in the brain because of its&#x27; PDE4B and PDE4D selectivity.<p>So what does this have to do with stress and nitric oxide? Everything! <a href="https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;28061969&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;28061969&#x2F;</a><p>But IMO this is a healthy function of the body. We should NOT be remembering our stressful experiences!
评论 #34757717 未加载
myself248超过 2 年前
Is that likely to interfere with the forgetting of dreams? I can&#x27;t imagine how cluttered my mind would be if that bizarre stuff didn&#x27;t blissfully fade within a few minutes of waking up.
评论 #34756615 未加载
评论 #34755900 未加载
cwillu超过 2 年前
…in mice.<p>“Havekes is quick to note that “this is all speculation,” but given the successes his team had in the lab, he believes his work can serve as a guidepost for researchers and pharmaceutical companies who are trying desperately to help folks retrieve their lost memories. Finally, and perhaps unsurprisingly, the researcher is just as enthusiastic about the new questions his work opens up as he is about the previously accumulated knowledge it may reveal.”
评论 #34756888 未加载
godelski超过 2 年前
I doubt the claim in the title, but I&#x27;ll add something probably more useful. I only personally know one person with an eidetic memory (what people think is &quot;photographic&quot;). That &quot;superpower&quot; affects them in a pretty negative way. People think of this power through very rose colored glasses, but there is also a dark side to it. You don&#x27;t just have a high recall for good times, your tool&#x27;s documentation, etc but you also have a high recall for any trauma and bad things that have happened to you. Since you have such high recall with high precision it is much closer to reliving the experience than a typical person&#x27;s memory would be. (there&#x27;s that popular image floating around of how well you can visualize an apple in your head. Eidetic people are on the extreme end while Aphantasia people are on the other) People with eidetic memories often over think things because they can recall a large swath of historical information to make judgements upon (and this leads to overload). It also freaks people out when you can recall what they had for breakfast several years ago on a specific day.<p>There are definitely advantages to this level of memory, but there are often disadvantages that come along with it. There was a reason evolution selected for brains that could forget and fuzz information. Fuzzing helps with abstraction. We even see some of this usefulness of forgetting when training neural networks (DNNs are __NOT__ akin to brains. Neither in respect to {hard,wet}ware nor algorithmically. But there are a weak similarities and similar abstractions).<p>It&#x27;s probably also worth adding that our memories are terrible in a different way. Not just in recall, but in that sometimes we just make shit up. This can be hard to distinguish and be problematic too. If you know any vivid or lucid dreamers ask them about their experiences (if someone is keeping a dream journal they&#x27;re likely to be a vivid dreamer. I stopped keeping a dream journal for this reason).<p>I&#x27;m sure someone that is way more knowledgeable about this could say more, fill in many gaps, and correct misunderstandings I have. I am not an expert (I study NNs, not brains). So if you are an _expert_ in this area, I&#x27;d love to learn more. Domain knowledge is often hard to come by and nuances matter.<p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Eidetic_memory" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Eidetic_memory</a>
评论 #34758713 未加载
smartscience超过 2 年前
The drug in the article is roflumilast, which seems to share some structure with the nootropic ampakine CX-546. I&#x27;ve never consumed that, but I&#x27;ve had some experience with IDRA-21 doing something like what the article describes, such as having vivid dreams of minor chart hits from decades ago that I&#x27;d previously gone a long time without being reminded of.
评论 #34756342 未加载
评论 #34756791 未加载
sva_超过 2 年前
Actual paper (OpenAccess): <a href="https:&#x2F;&#x2F;www.cell.com&#x2F;current-biology&#x2F;fulltext&#x2F;S0960-9822(22)01906-6" rel="nofollow">https:&#x2F;&#x2F;www.cell.com&#x2F;current-biology&#x2F;fulltext&#x2F;S0960-9822(22)...</a><p>Press release: <a href="https:&#x2F;&#x2F;www.eurekalert.org&#x2F;news-releases&#x2F;975994" rel="nofollow">https:&#x2F;&#x2F;www.eurekalert.org&#x2F;news-releases&#x2F;975994</a>
lgats超过 2 年前
Similar dscussion on Reddit (2020) <a href="https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;Nootropics&#x2F;comments&#x2F;izplmo&#x2F;roflumilast_enhances_verbal_memory_selective&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;Nootropics&#x2F;comments&#x2F;izplmo&#x2F;roflumil...</a> also links to a few other studies
gjm11超过 2 年前
... in mice.
评论 #34756204 未加载
评论 #34756028 未加载
ASalazarMX超过 2 年前
The &quot;magic FDA-approved asthma drug&quot; is roflumilast, just in case you were wondering.<p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Roflumilast" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Roflumilast</a>
gardenfelder超过 2 年前
full paper <a href="https:&#x2F;&#x2F;www.cell.com&#x2F;current-biology&#x2F;fulltext&#x2F;S0960-9822(22)01906-6" rel="nofollow">https:&#x2F;&#x2F;www.cell.com&#x2F;current-biology&#x2F;fulltext&#x2F;S0960-9822(22)...</a>
msla超过 2 年前
I notice they eventually changed the lying headline this was originally posted with.<p>Is there a better way to prevent lying headlines in the future?
评论 #34757007 未加载
hprotagonist超过 2 年前
those murine preschool teachers ought to be running scared now.