A nasal spray protects against coronavirus including immune-evasive variants

Full article with supplemental data:<p><a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2021.12.28.474326v1.full.pdf" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2021.12.28.474326v1....</a><p>&gt; &quot;The intranasal dose of TriSb92 that should be administered to susceptible persons prior to events involving a risk for SARS-CoV-2 exposure remains to be established but is likely to be substantially lower than extrapolation of our current data on mice that were challenged by inoculation of the rather massive amount of 2x105 PFU of SARS-CoV-2 into their respiratory tract.&quot;<p>Side effects might be an issue but that should show up in well-designed clinical trials. It sounds like something that people working in infectious clinical settings might want to use, maybe immunocompromised people who have to go out in public, but otherwise, for general use seems iffy in terms of efficacy.

There&#x27;s already some nasal sprays around that supposedly protect against Covid-19 in a similar way. However many places online just echo the copy from the manufacturers about the efficiency. Has anyone tried those sprays and can share their experience?

More:<p>- <a href="https:&#x2F;&#x2F;www.pandemblock.com&#x2F;products" rel="nofollow">https:&#x2F;&#x2F;www.pandemblock.com&#x2F;products</a><p>- <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41467-023-37290-6" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41467-023-37290-6</a><p>Q: how would this be to take, if it&#x27;s ever human certified? Are there similar nasal immunity products, using similar molecular mechanisms?

Seems like a cool concept for future pandemics. These types of things are always cool to see even if they are a bit late.

Since the initial outbreak of SARS-CoV-2 I have kept bottles of Betadine nasal spray around. They say &quot;clinically proven to reduce cold symptoms on the packaging,&quot; always seemed reasonable to think it might work as well against this coronavirus as all the others.

My housemate was part of this study. He noticed his hayfever stopped.

For how long does the spray protect you? Is this something you&#x27;d use on a daily basis?

So... several years out for use in the US assuming it passes clinical trials?

This was tested in mice. I&#x27;ll hold my breath until I see human trials.

How does this work? It sounds like its not a vaccine (your immune system is not invoked) but something that attaches to the spike protein and inhibits it from entering cells. But how could a nasal spray last a long time? Is this something that needs to be used continuously?

(In mice)

that would pose a problem for the medical state. how can you enforce &quot;vaccination&quot;?

I wonder if a nasal spray (or a tablet) is enough to make vaccine deniers change their minds. Sometimes you wonder, is all the ridiculousness of their protest because they&#x27;re just afraid of needles and injections?

There are lots of nasal sprays that may potentially be protective against covid, e.g. Betadine Cold Defence, but almost all of them are banned for sale in the US. But you can buy pure saline nasal spray for a couple dollars at Target, which itself is likely protective.

Dr. McCullough has been recommending people use diluted povodone iodide solution for a couple years already. I&#x27;ve done this anytime I felt cold symptoms coming on and they usually disappear within a few hours.<p>It&#x27;s pretty much common sense, most bacteria and viruses for respiratory infections live in the upper respiratory tract and multiply there. Kill them at the source and your infection tends to resolve much faster...