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Rapamycin: The unlucky history of an anti-aging drug

203 点作者 theNewMicrosoft大约 2 年前

8 条评论

tysam_and大约 2 年前
Anti-aging is a hard problem, Rapamycin is most certainly not the most powerful anti-aging drug from my best understanding, it just targets 1 of 7 or 8 critical areas that are implicated in the aging formula.<p>If you want to start down the rabbithole (SENS talks can be trusted and are good, well-backed by science, etc etc. Have been derailed by some drama recently, but still, they&#x27;ve really done a lot) then you can start by going to the rejuvenation roadmap: <a href="https:&#x2F;&#x2F;www.lifespan.io&#x2F;road-maps&#x2F;the-rejuvenation-roadmap&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.lifespan.io&#x2F;road-maps&#x2F;the-rejuvenation-roadmap&#x2F;</a><p>A little further (Aubrey de Grey, from SENS originally): <a href="https:&#x2F;&#x2F;www.ted.com&#x2F;talks&#x2F;aubrey_de_grey_a_roadmap_to_end_aging?language=tt" rel="nofollow">https:&#x2F;&#x2F;www.ted.com&#x2F;talks&#x2F;aubrey_de_grey_a_roadmap_to_end_ag...</a><p>If you want to lose 4-5+ hours (minimum -- think TVTropes level of rabbithole addiction here), then here is your next free joyride. It&#x27;s a fun one, I&#x27;ve been pretty interested in it as it&#x27;s continued to have developed. Have fun reading the saga: <a href="https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;sleephackers&#x2F;comments&#x2F;ohfetn&#x2F;turnbuckle_longecity_mitochondrial_fissionfusion&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;sleephackers&#x2F;comments&#x2F;ohfetn&#x2F;turnbu...</a>
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34679大约 2 年前
There&#x27;s a great Radiolab episode on this topic and the person who first isolated it.<p><a href="https:&#x2F;&#x2F;radiolab.org&#x2F;podcast&#x2F;dirty-drug-and-ice-cream-tub" rel="nofollow">https:&#x2F;&#x2F;radiolab.org&#x2F;podcast&#x2F;dirty-drug-and-ice-cream-tub</a>
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starchild_3001大约 2 年前
Many of us know and follow rapamycin&#x27;s story. There are some Drs in USA who&#x27;re willing to prescribe it for longevity. I do hope some billionare will be willing to spend a few million on it to test it in clinical trials. Surely one of the most promising molecules out there, and very little sides when dosed intermittently.
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CapstanRoller大约 2 年前
Rapamycin is also being studied as a booster drug to ketamine for treatment-resistant depression<p><a href="https:&#x2F;&#x2F;www.bbrfoundation.org&#x2F;content&#x2F;surprising-clinical-trial-ketamines-antidepressant-effects-lasted-longer" rel="nofollow">https:&#x2F;&#x2F;www.bbrfoundation.org&#x2F;content&#x2F;surprising-clinical-tr...</a>
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snvzz大约 2 年前
Tangentially related: Fable of the Dragon-Tyrant[0].<p>0. <a href="https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=cZYNADOHhVY">https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=cZYNADOHhVY</a>
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EdwardDiego大约 2 年前
The part where a compound first investigated as an antifungal improves longevity of fungi wasn&#x27;t really explored, but eh?<p>Is it controlling fungi that infect other fungi or something?
mannyv大约 2 年前
Sounds like this would have been a great candidate for covid patients with immune system issues...like cytokine storms etc.
schmichael大约 2 年前
Sorry for the meta-commentary but…<p>HN’s anti-aging obsession is <i>wild.</i><p>I get zero anti-aging content from any other news source, user submitted or otherwise, and yet without fail it seems like there’s at least one anti-aging article a week on HN. Any other topic I find on HN I run into elsewhere: space, JavaScript, crypto, lisp, etc etc. Only on HN do I regularly see anti-aging “news” promoted.<p>The discussions are all about the same: it’s a scam! It’s worth a shot! More research is needed! Anti-aging is unnatural! Anti-aging is a biological imperative!<p>idk it must have fans to get so consistently upvoted, but I do not get the appeal.
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