首页

31 条评论

jmpman大约 2 年前
I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself to keep drinking, say if my good friends are in town and we’re going out all night? Sure, but there’s some reward center that’s no longer lighting up. I just get drunker, but it’s not more pleasurable. I was never a big drinker at home by myself. Maybe a glass of wine or two with dinner if my in-laws are coming over. Now I’ve literally had zero drinks at home by myself. Seems to have started changing about 3 month in.<p>Work also seems more interesting, but my untreated ADHD seems to be getting worse.
评论 #36009689 未加载
评论 #36009630 未加载
评论 #36009489 未加载
评论 #36008589 未加载
评论 #36015048 未加载
评论 #36008316 未加载
评论 #36008945 未加载
评论 #36009296 未加载
评论 #36008525 未加载
lumb63大约 2 年前
I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly.<p>The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energy and has developed issues with her bladder, circulatory system, joints, thyroid, and digestive system since starting Ozempic. I’m not saying it’s due to Ozempic, but I am saying all these issues have cropped up in the few months since she started taking it, and she never had any chronic health issues prior. At least she lost some weight, I guess.
评论 #36008186 未加载
评论 #36004680 未加载
评论 #36008635 未加载
评论 #36007945 未加载
评论 #36004278 未加载
评论 #36007879 未加载
评论 #36004311 未加载
评论 #36007912 未加载
评论 #36008234 未加载
评论 #36004284 未加载
评论 #36008975 未加载
评论 #36007598 未加载
评论 #36007919 未加载
评论 #36004142 未加载
评论 #36007811 未加载
jshaqaw大约 2 年前
It’s interesting to me how much of the hostility to this drug has a moral dimension. I am quite fit for my middle age. It’s a relative superpower which confers a degree of status in this world. It’s not why I originally became fit 5 or so years ago but it’s something I increasingly notice or to be clear others notice and comment on.<p>I think the “fit” of the world get inherently uncomfortable that our relative social currency is being “devalued” if everyone can be like us with an “unearned” pill. And it comes out as hostility and skepticism.<p>I admit haven’t done much research on this particular topic. History should caution us that serious medication like this often has serious side effects which are not apparent early on. I get that. But unlike many others I don’t “hope” that happens like some kind of moral balancing. I get that reaction. In my gut I have that “I did it with willpower and lifestyle and sweat and these people shouldn’t just get it at CVS.” But that’s just the primate status brain talking.<p>Not that it impacts the outcome but I sincerely hope these drugs can improve people’s lives without significant negative problems. I can find my relative status elsewhere or better yet try to grow up past such impulses.
评论 #36014465 未加载
评论 #36016851 未加载
LazyMans大约 2 年前
Yes. On a compounded semaglutide. I can finally control my hunger and a nice unexpected effect has been losing a desire to drink large quantities of alcohol. I don’t drink during the week anyway, but it seems to be the volume that turns me off to drinking. Thus a few cocktails are all I can tolerate. For context, Im 30, male, would be defined as a binge drinker on weekends. Oh, and I’ve given up nicotine entirely. I can’t tell if the drug is helping or it was just a point in my life that I finally decided I accept it makes me feel ill most of the time.
评论 #36008419 未加载
评论 #36009210 未加载
评论 #36009690 未加载
评论 #36009829 未加载
mym1990大约 2 年前
A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true?<p>From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.
评论 #36004593 未加载
评论 #36007752 未加载
评论 #36004082 未加载
评论 #36014537 未加载
评论 #36004097 未加载
评论 #36004404 未加载
评论 #36003880 未加载
评论 #36010761 未加载
评论 #36004324 未加载
评论 #36004041 未加载
评论 #36010056 未加载
评论 #36011274 未加载
评论 #36015632 未加载
评论 #36004199 未加载
评论 #36004037 未加载
glonq大约 2 年前
What happens when you reach your target weight with drugs like this?<p>After having learned <i>potentionally nothing</i> about nutrition, exercise, and self-control, are you stuck on these meds for life out of fear of binge-eating back to your original weight?<p>FWIW I&#x27;m on a hundred-pound roller coaster ride from 300lbs to 200lbs; currently ~215. I&#x27;ve learned a lot about discipline and sustainable habits along the way.
评论 #36006354 未加载
评论 #36007714 未加载
评论 #36009762 未加载
评论 #36007887 未加载
评论 #36008435 未加载
评论 #36008118 未加载
rektide大约 2 年前
I&#x27;m surprised Ozempic gets all the press. Supposedly Mounjaro is all that and more.<p>The wonderful Paul Ford has the best writeup I&#x27;ve seen that discusses these more meta levels, the post-human implications of a drug we can genuinely widescalely reprogram ourselves with. Paul&#x27;s so great. <a href="https:&#x2F;&#x2F;www.wired.com&#x2F;story&#x2F;new-drug-switched-off-appetite-mounjaro&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.wired.com&#x2F;story&#x2F;new-drug-switched-off-appetite-m...</a> <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=34660232" rel="nofollow">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=34660232</a>
评论 #36008124 未加载
评论 #36003939 未加载
评论 #36006277 未加载
评论 #36004222 未加载
SamoyedFurFluff大约 2 年前
How long is the research info ozempic and other hormonal weight loss drugs? Remember the last miracle drug that went to the market for weight loss had to be retracted for killing people or damaging their hearts to the tune of over 10 billion dollars in damages paid out.
评论 #36008538 未加载
评论 #36008297 未加载
评论 #36008256 未加载
评论 #36008262 未加载
xvilka大约 2 年前
I tried Ozempic for two months but wasn&#x27;t able to continue - the gastrointestinal side effects are unbearable. I can confirm lack of desire to eat and drink alcohol. The hunger didn&#x27;t go away but after a few bites of anything it quickly evaporated. After dropping the drug the hunger steeply increased, even higher than before, that was hard to contain.
monkeycantype大约 2 年前
the genetics of obesity are amazing. we all have a unique combination of genes, and epigenic features that influece the endocrine and neuronal pathways that drive the desire to eat, these different genotypes affect our behaviour. Ozempic is putting a thumb on the scales of this pathway, but this pathway is balanced differently in all of us. Think of the most hungry you have ever been, in some people this never stops, in others it&#x27;s dialed up or down.<p>there are some great papers on fat labradors that hint at how these different genotypes are linked to our desire to eat and how that shifts our behaiour. Guide dogs are highly selected for trainability, and positive reinforcement with food reward plays an important role in their training. I think it was Yeo, found 22% of pet Labradors and 80% of Labrador guide dogs sampled carried a 14 BP deletion in the POMC gene, which forms part of this pathway.<p><a href="https:&#x2F;&#x2F;doi.org&#x2F;10.1007&#x2F;s00125-016-4187-x" rel="nofollow">https:&#x2F;&#x2F;doi.org&#x2F;10.1007&#x2F;s00125-016-4187-x</a> <a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC4873617&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC4873617&#x2F;</a>
arcadeparade大约 2 年前
Some people really love to moralize and cite anecdotes about Ozempic.
评论 #36008067 未加载
MagicMoonlight大约 2 年前
I was always of the opinion that being fat was a moral failing. Trying the drug really changed that.<p>Normies have it so easy. They take one bite and feel full. My brain would scream at me continuously to try and make me eat and would never be satisfied.
评论 #36010955 未加载
评论 #36010751 未加载
fintechie大约 2 年前
I was about to get on semaglutide and after extensive research I thought &quot;wait, the results won&#x27;t be much better than the periods of IF I&#x27;ve had in the past, and the reported benefits are similar&quot;, and without side effects. Dropping 30 pounds in 3 months? easy to achieve with the Warrior Diet or OMAD versions of IF.<p>The results are exactly the same... you fill full eating less quantity, cravings disappear after 1-2 weeks, increased focus and enhanced mental state. But yeah, you need some self-discipline, tons of coffee&#x2F;matcha and water.<p>I&#x27;ve concluded that semaglutide is not for me. Just like self-discipline in pills, with potential side effects. So better to give IF another go... I&#x27;m in the 4th week and dropped 10lbs already.
TeeMassive大约 2 年前
I am taking Contrave to lose weight. Lost 30 lbs in 4 months. It is a drug that&#x27;s composed of an anti-depressant and an opioid antagonist. Together they have a synergistic effect that represses binging envy and cuts appetite.<p>It also has a repressive effect on drinking and smoke, to my great surprise. And it also has had an effect on my addiction to video games.<p>Drugs companies get a lot of slack (most of the time deserving) but sometimes they create miracles pills.
crakenzak大约 2 年前
Now if only it didn’t cost so damn much every month even under insurance =(
评论 #36008147 未加载
评论 #36003881 未加载
评论 #36003890 未加载
评论 #36003934 未加载
beefman大约 2 年前
<a href="https:&#x2F;&#x2F;archive.is&#x2F;MfXlm" rel="nofollow">https:&#x2F;&#x2F;archive.is&#x2F;MfXlm</a>
caycep大约 2 年前
it&#x27;s funny in that a few years ago we were (and still are) excited by the potential cellular protective properties of GLP1 agonists, not just in the pancreas but in brain glial cells or whatnot. So much so that it seems to be the most neuroprotective of recent candidates for Parkinson&#x27;s disease disease-modifying-therapies (DMTs).<p>to whit, (like botox), all the initial promises of the stuff have been waaaay overshadowed by...cosmetic value.<p>(I&#x27;m oversimplifying a bit...for those who are morbidly obese, yes, the weight loss really helps, but then they also have diabetes most likely which is the primary indication of the drug)
PostOnce大约 2 年前
Exercise is free and the side effects are you get stronger, more energetic, and better looking.<p>Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes.<p><a href="https:&#x2F;&#x2F;www.ozempic.com&#x2F;faqs.html" rel="nofollow">https:&#x2F;&#x2F;www.ozempic.com&#x2F;faqs.html</a><p>edit: many point out calorie intake is the real problem, it&#x27;s true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. Still, both are free and have more benefits.
评论 #36008867 未加载
评论 #36008930 未加载
评论 #36009073 未加载
评论 #36008870 未加载
评论 #36009486 未加载
评论 #36009609 未加载
评论 #36008875 未加载
omgmajk大约 2 年前
I was on ozempic for a bit but it raised my resting pulse from 65ish to 95ish just sitting at my computer so I had to stop taking it.
EdwardDiego大约 2 年前
From my experience of addiction, suppressing the sensation of pleasure derived, is only the start.<p>People who are addicted will repeat the behaviour even without the neurochemical response. Consider the ritual of the addiction as a form of self-soothing.<p>You have to treat the patterns we&#x27;ve trod in our own minds, as well as removing that biological reinforcement.
Jun8大约 2 年前
So, instead is suppressing the <i>desire</i> to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized.<p>Is this faster-than-light-like impossible daydream or is there any plausible path to it?
评论 #36013605 未加载
评论 #36009875 未加载
评论 #36008750 未加载
评论 #36009620 未加载
评论 #36009019 未加载
评论 #36009345 未加载
评论 #36008630 未加载
akiselev大约 2 年前
<a href="https:&#x2F;&#x2F;archive.ph&#x2F;1waP9" rel="nofollow">https:&#x2F;&#x2F;archive.ph&#x2F;1waP9</a>
throwaway5959大约 2 年前
Wasn’t this the plot of the Firefly movie? It didn’t work out well for them.
评论 #36007762 未加载
myshpa大约 2 年前
Psilocybin too.
clementmas大约 2 年前
Is this mostly a US drug? I never heard about it in France. I can&#x27;t believe people love it so much without thinking about the actual source of their problem.
评论 #36009907 未加载
评论 #36009257 未加载
jamesfisher大约 2 年前
<a href="https:&#x2F;&#x2F;archive.is&#x2F;BUo29" rel="nofollow">https:&#x2F;&#x2F;archive.is&#x2F;BUo29</a>
olegious大约 2 年前
Just a heads up “weight loss” is a poor metric if it comes at the cost of lean muscle mass. It seems that 39% of weight loss associated with Ozempic comes from lean muscle mass which isn’t great.<p><a href="https:&#x2F;&#x2F;peterattiamd.com&#x2F;the-downside-of-glp-1-receptor-agonists&#x2F;" rel="nofollow">https:&#x2F;&#x2F;peterattiamd.com&#x2F;the-downside-of-glp-1-receptor-agon...</a>
评论 #36009558 未加载
评论 #36011904 未加载
评论 #36009570 未加载
评论 #36009583 未加载
tomcam大约 2 年前
Ozempic did nothing for me
Eumenes大约 2 年前
Congrats, you&#x27;re now a lifetime subscriber to big pharma
ingenika大约 2 年前
maybe useful to treat drug addiction ?
Avshalom大约 2 年前
&quot;Semaglutide does not dull all pleasure, people taking the drug for weight loss told me. They could still enjoy a few bites of food or revel in finding the perfect dress; they just no longer went overboard. Anhedonia, or a general diminished ability to experience pleasure, also hasn’t shown up in cohorts of people who take the drug for diabetes, says Elisabet Jerlhag Holm, an addiction researcher at the University of Gothenburg.&quot;<p>So it doesn&#x27;t dull <i>all</i> pleasure just <i>almost all</i> so it&#x27;s not <i>technically</i> anhedonia...<p>I dunno, still seem pretty fucking bleak to me.
评论 #36007586 未加载
评论 #36007689 未加载
评论 #36007589 未加载
评论 #36008035 未加载