This study shows that metobolic markers after fasting are related to physiological differences in the subjects.<p>The full text can be accessed via <a href="https://www.researchgate.net/publication/368542960_Insulin_resistance_after_a_3-day_fast_is_associated_with_an_increased_capacity_of_skeletal_muscle_to_oxidize_lipids" rel="nofollow noreferrer">https://www.researchgate.net/publication/368542960_Insulin_r...</a><p>Here is an auto-generated summary from scisummary.com:<p><i>Introduction and Study Design</i><p>This scientific article examines the role of muscle fiber composition in the metabolic responses to short-term starvation. The study involved two groups of healthy young subjects, one with a high proportion of type I muscle fibers and the other with a low proportion. The subjects were studied after an overnight fast and after a 3-day fast, which induces insulin resistance.<p><i>Impact of Muscle Fiber Composition on Glucose Tolerance and Insulin Sensitivity</i><p>The results show that glucose tolerance deteriorated to a similar degree in both groups after starvation. However, whole body insulin sensitivity decreased markedly in the group with a high proportion of type I fibers, while the decrease was smaller in the group with a low proportion. This suggests that loss of insulin sensitivity after short-term starvation is a function of muscle fiber composition.<p><i>Influence of Muscle Fiber Composition on Lipid Oxidation</i><p>The study also found that the capacity of muscle fibers to oxidize lipids was significantly higher in the group with a high proportion of type I fibers. This indicates that the loss of insulin sensitivity in this group is associated with an elevated capacity of muscle to oxidize lipids, rather than a decreased capacity.<p><i>Implications and Future Research Directions</i><p>The findings suggest that lipid-mediated insulin resistance may be influenced by the capacity of muscle fibers to oxidize fats. The study provides insights into the mechanisms underlying insulin resistance and the role of muscle fiber composition in metabolic responses to fasting. Further research is needed to fully understand the relationship between muscle fiber composition, lipid metabolism, and insulin resistance.