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Antioxidants found to spur cancer growth and metastasis in mice

150 点作者 danielam超过 1 年前

17 条评论

pcorsaro超过 1 年前
The debate about Vitamin C in the cancer world is never ending. My wife had stage IV colon cancer a few years ago, and we went through tons and tons of research to try and find things to supplement her chemotherapy. A lot of the "alternative" medicine people suggest doing extremely high dose Vitamin C intravenously because supposedly at higher doses, it becomes oxidative and generates free radicals in the blood stream which can kill a lot tumor types. Her oncologist didn't like the idea because there is also lots of research that says it spurs growth in tumors. He said that Vitamin C gets studied so much because it's cheap to get, but it's never really produced any meaningful results. There was a study he liked about taking extremely high doses of Vitamin D, but I can't really remember why.
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tptacek超过 1 年前
In mice (with xenografted tissue).<p>They&#x27;ve been reporting this since 2015:<p><a href="https:&#x2F;&#x2F;newatlas.com&#x2F;medical&#x2F;antioxidants-stimulate-blood-vessel-growth-cancer-tumors&#x2F;" rel="nofollow noreferrer">https:&#x2F;&#x2F;newatlas.com&#x2F;medical&#x2F;antioxidants-stimulate-blood-ve...</a><p>The actual press release from Karolinska might be more informative and a better link than whatever New Atlas is:<p><a href="https:&#x2F;&#x2F;news.ki.se&#x2F;antioxidants-stimulate-blood-flow-in-tumours" rel="nofollow noreferrer">https:&#x2F;&#x2F;news.ki.se&#x2F;antioxidants-stimulate-blood-flow-in-tumo...</a>
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Sunspark超过 1 年前
For ascorbic acid (vitamin C) specifically, there is such a thing as too much of it.. in humans, the level that is too much is when it gives you loose stools.. if you back off that, then the body is likely using what it needs.<p>Most animals make vitamin C internally in the amounts they need. We are only one of a handful that do not, because we have a mutation that prevents us from finishing the process, otherwise we would also be making it ourselves too.<p>Animals don&#x27;t drop dead left and right from cancer. I would suggest if one tries to eat a balanced diet then this will help with avoiding cancer.<p>Lastly, the longer you live, the more certain it becomes that you will get cancer of any type. What we are doing here is trying to live healthy enough that we die before we live long enough for cancer to become a problem.
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joshuajill超过 1 年前
I find the fact that media keeps talking about cancer as one single disease unhelpful at best.<p>Look at what the title of the research article is: &quot;Antioxidants stimulate BACH1-dependent tumor angiogenesis&quot;<p>The researchers conclusion: &quot;We conclude that BACH1 is an oxygen- and redox-sensitive angiogenesis transcription factor.&quot;<p>Then compare how the author of the article put it.
ramoz超过 1 年前
Similar thread from just the other day: <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=37349870">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=37349870</a>
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throwawaymaths超过 1 年前
Kind of hilariously, James Watson was on a crusade about this, specifically yowling about how Pauling was totally wrong to megadose C (he argued specifically from the Warburg hypothesis) but it was around then that he started making tone-deaf, arguably racist comments (...also many racist comments against scots irish americans), and he got canceled and i think everyone stopped listening to him writ large.
alistoriv超过 1 年前
So... they support anabolic processes. Shall we avoid eating and drinking too?
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cjbenedikt超过 1 年前
One more reason why very little research goes into that area is that the pharma industry isn&#x27;t interested in a &quot;cheap&quot; solution. It is nigh impossible to find grants for any research to that end. However, some work sounds promising <a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC9231292&#x2F;#:~:text=Recent%20reports%20have%20also%20shown,chemotherapy%20%5B34%2C35%5D" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC9231292&#x2F;#:~:tex...</a>.
alaaf超过 1 年前
Is this about concentrated synthetic vitamin C or about the natural form? From a chemistry perspective the same, but the natural one comes in a different &quot;package&quot; of other substances (vitamin C complex). I wonder if the effect is the same.
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jasfi超过 1 年前
Does this mean a bad diet is preferable when you&#x27;re fighting off cancer?
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kypro超过 1 年前
Isn&#x27;t this already known? The reason I only take a low dose of Vit E is because higher doses can increase the risk of cancer – like I assumed is true of all antioxidants?
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LorenPechtel超过 1 年前
If it helps the body it likely also helps the cancer.
nmitchko超过 1 年前
With all we see around cancer, it&#x27;s time to study fembendazole and other anti-tubulins seriously.
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tylerekahn超过 1 年前
The Block Center does high dose intravenous Vitamin C as part of their chemo+complementary regimen.
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ginko超过 1 年前
Can&#x27;t wait for fruit to come with a cancer warning.
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ipnon超过 1 年前
“Dosis sola facit venenum.”
haunter超过 1 年前
Everything [in excess] causes cancer