The major genetic risk factor for severe Covid-19 is inherited from Neanderthals

Protective factor outweighs the risk factor from the Neanderthal locus.<p>Conversely, the protective effect of the HLA-A<i>02:01, B</i>18:01, DRB*03:01 three-loci extended haplotype in the Sardinian population was shown to efficiently contrast the high risk of a severe and devastating outcome of the infection predicted for carriers of the Neanderthal locus [OR 15.47 (95% CI 5.8 – 41.0), p &lt; 0.0001].<p><a href="https:&#x2F;&#x2F;www.frontiersin.org&#x2F;articles&#x2F;10.3389&#x2F;fimmu.2022.891147&#x2F;full" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.frontiersin.org&#x2F;articles&#x2F;10.3389&#x2F;fimmu.2022.8911...</a>

<i>It is notable that the Neanderthal risk haplotype occurs at a frequency of 30% in south Asia whereas it is almost absent in east Asia</i> - look at India and China on the map <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41586-020-2818-3&#x2F;figures&#x2F;3" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41586-020-2818-3&#x2F;figures&#x2F;3</a> (?)<p>What about other coronaviruses ?

I knew it was the Neanderthals all along.<p>They’re still here you know.