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Are the Longevity Benefits of Acarbose Rooted in Its Role on the Gut Microbiota?

74 点作者 rpkoven超过 1 年前

6 条评论

ramraj07超过 1 年前
For anyone even remotely interested in learning how research happens and how research should happen if it happens well, you should listen to the Peter Attia podcast with Richard Miller who runs the ITP program mentioned here. It’s definitely the most thoughtful research program that I can think of that’s currently running. <a href="https:&#x2F;&#x2F;peterattiamd.com&#x2F;richardmiller&#x2F;" rel="nofollow noreferrer">https:&#x2F;&#x2F;peterattiamd.com&#x2F;richardmiller&#x2F;</a><p>Having said that Acarbose was still only shown to extend life in mice. The moment something is about gut microbiome I start losing confidence in the ability of mouse models in predicting human behavior.<p>When I originally heard about Acarbose in this episode I looked up Reddit as I usually do and the scant mentions all recalled smelly flatulence as a gross side effect. Take that for what you want! Not to mention it worked only in male mice and we have no idea how! This is not confidence inducing especially if you’re committing to becoming horrendously smelly!
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JumpCrisscross超过 1 年前
&gt; <i>acarbose was one of five molecules shown to increase lifespan</i><p>Rapacmycin, acarbose, glycine, canagliflozin and 17-a-estradiol [1]. Acarbose’s side effects include “flatulence (78% of patients) and diarrhea (14% of patients)” [2]. (It also appears to be hard on the liver.)<p>[1] <a href="https:&#x2F;&#x2F;www.nia.nih.gov&#x2F;research&#x2F;dab&#x2F;interventions-testing-program-itp&#x2F;supported-interventions" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.nia.nih.gov&#x2F;research&#x2F;dab&#x2F;interventions-testing-p...</a><p>[2] <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Acarbose" rel="nofollow noreferrer">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Acarbose</a>
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aszantu超过 1 年前
I&#x27;d be interested to see if acarbose extends the life of obligate carnivores.<p>As far as I know the mice get a high sugar&#x2F;starch diet, but afaik nobody ever stopped to see if they live longer on a high fat&#x2F;high protein diet or not. not sure about this though.
mfer超过 1 年前
At the center of all of this is short chain fatty acids. Higher levels of SCFAs are already known to be good for your health. With a healthy diet they can be driven up, too.
formvoltron超过 1 年前
isn&#x27;t it due to lowering blood sugar spikes? If so, I noticed that my blood sugar does not spike after a meal if I just walk casually on a treadmill for maybe 15 minutes after eating.
IAmGraydon超过 1 年前
Always be wary of headlines structured like this:<p>“Are the Longevity Benefits of Acarbose Rooted in Its Effect on the Gut Microbiota?”<p>It presents something as fact (Acarbose has longevity benefits) in the form of a question. This sort of structure implies that it’s already been widely accepted as fact that this is true without overtly saying it and it’s commonly used in marketing to slip things by the brain’s natural BS filter. You can also commonly see this in agenda-driven media headlines.<p>The truth is that Acarbose hasn’t been shown to have longevity benefits in anything but mice, and even that research is questionable at best.<p>If you need further proof that this is marketing, notice the “products” button on the upper right, where the website that published this article happens to sell…you guessed it…Acarbose. The guy who wrote the article, Daniel Tawfik, is the founder of Zenpatient, the online pharmacy used to sell this and other medications.<p>We’re being marketed to. I’m flagging this post. It’s spam.
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