As a layman, I find this extremely enlightening. Even now, (anecdotally) a lot/most people describe it as primarily a respiratory disease.<p>From the OP article:<p>> "Using nasal swabs and autopsy tissues from affected patients and animal models, researchers found that the virus blocks specific genes that use oxygen to create ATP, forcing the body to deplete finite energy reserves in the body. Without an energy source, cells throughout the body begin to starve, with the cells powering the brain and the heart suffering the most."<p>This is the first thing I've read which actually makes bloody sense.<p>A 2020 study linked below:<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443557/#:~:text=Of%20the%2084%20COVID%2D19,73.3%25%2C%20respectively)%2C%20circulatory" rel="nofollow noreferrer">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443557/#:~:tex...</a><p>From the aforementioned 2020 study:<p>"Of the 84 COVID-19 cases with known direct cause of death, the top 3 common direct causes of death were multiple organ failure (67.9%), circulatory failure (20.2%), and respiratory failure (11.9%), and were similar (P = 0.50) for males and females: multiple organ failure (64.8% vs 73.3%, respectively), circulatory failure (24.1% vs 13.4%, respectively), and respiratory failure (11.1% vs 13.3%, respectively)."