> Interventions: Participants were randomized to 1 of 3 groups: 8-hour TRE (eating 12 to 8 pm only, without calorie counting), CR (25% energy restriction daily), or control.<p>Longer fasting periods, including 16/8 TRE and alternate-day fasting, have been shown to cause a disproportionate amount of lean body mass loss: <a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771095" rel="nofollow noreferrer">https://jamanetwork.com/journals/jamainternalmedicine/fullar...</a><p>>In this RCT, a prescription of TRE did not result in weight loss when compared with a control prescription of 3 meals per day. Time-restricted eating did not change any relevant metabolic markers. Finally, there was a decrease in ALM in the TRE group compared with CMT. Together, the results of this study (1) do not support the efficacy of TRE for weight loss, (2) highlight the importance of control interventions, and (3) offer caution about the potential effects of TRE on ALM. Future studies should be aimed at understanding the effects of early vs late TRE and protein intake or timing as a means to offset the loss in ALM.<p>ALM = Appendicular (i.e., limb) Lean Mass.<p>One of the authors of this study, Ethan Weiss, is a cardiologist and was a big proponent of TRE, but after the results of his own study came in showing drastic loss of LBM in TRE group (to the point that most of the weight lost was LBM) and no added benefit, he completely stopped doing TRE, stopped recommending it, and went to Twitter and the news media to publicize the harm, eg: <a href="https://www.insider.com/new-research-finds-intermittent-fasting-may-not-boost-weight-loss-2020-9" rel="nofollow noreferrer">https://www.insider.com/new-research-finds-intermittent-fast...</a><p>X isn't showing his Twitter thread, but there's a copy of it here:
<a href="https://old.reddit.com/r/ScientificNutrition/comments/j1fav8/effects_of_timerestricted_eating_on_weight_loss/g71eria/?context=3" rel="nofollow noreferrer">https://old.reddit.com/r/ScientificNutrition/comments/j1fav8...</a><p>>In the in-person cohort, the average weight loss in the TRE group was 1.70 kg. Of this, 1.10 kg <i>(~ 65% wt lost) was lean mass</i>; only 0.51 kg of weight lost was fat mass. Loss of lean mass during weight loss is normal but typically accounts for 20% to 30% of total weight loss<p>>So in summary: 1) no matter how you slice it, prescription of TRE is not a very effective weight loss strategy; 2) There was no advantage to TRE when compared to a proper control group; 3) What weight was lost looked to come more from muscle mass than fat mass