In the trial, 29 of 30 eligible patients with sickle-cell disease went from multiple pain crises every year to zero in 12 months following treatment.<p>The results are so astounding that this therapy, from Vertex Pharmaceuticals and CRISPR Therapeutics, became the first CRISPR medicine ever approved, with U.K. regulators giving the green light earlier this month; the FDA appears prepared to follow suit in the next two weeks.