Using blood analysis and advanced metabolomic techniques, researchers have uncovered distinct metabolic characteristics in people with severe depression and suicidal thoughts, with over 90% accuracy in distinguishing them from healthy people.<p>These characteristics included abnormalities in fat metabolism, increased RNA turnover, and mitochondrial dysfunction.<p>About 75% of the metabolic abnormalities were individualized, suggesting the need for personalized treatment approaches.<p>The study suggests nutrient deficiencies, including carnitine, CoQ10, and folic acid, may play a role.<p>Carnitine is important for fatty acid transport into mitochondria for energy production.<p>CoQ10 is involved in mitochondrial energy generation and acts as an antioxidant.<p>Folic Acid is essential for DNA synthesis and repair, and amino acid metabolism.