TE
科技回声
首页24小时热榜最新最佳问答展示工作
GitHubTwitter
首页

科技回声

基于 Next.js 构建的科技新闻平台,提供全球科技新闻和讨论内容。

GitHubTwitter

首页

首页最新最佳问答展示工作

资源链接

HackerNews API原版 HackerNewsNext.js

© 2025 科技回声. 版权所有。

Researchers discover physical cause of long Covid tiredness

103 点作者 rdtennent超过 1 年前

15 条评论

kick_in_the_dor超过 1 年前
&gt; we saw that the mitochondria of the muscle, also known as the <i>energy factories of the cell</i><p>*Ahem*, <i>powerhouse of the cell</i><p>Jokes aside, this is a terrifying stat: &quot;Although the majority of people infected with the SARS-CoV-2 virus recover within weeks...around one in eight will get long-COVID. Symptoms in patients with long-COVID...include severe cognitive problems (brain fog), fatigue, exercise intolerance, autonomic dysregulation...&quot;
评论 #38868761 未加载
评论 #38868569 未加载
评论 #38874852 未加载
评论 #38870439 未加载
评论 #38868823 未加载
tasty_freeze超过 1 年前
The title is a lot more exciting than what is actually being claimed. They say that malfunctioning mitochondria are to blame ... but there is no insight into why the mitochondria are malfunctioning.<p>My wife, a formerly energetic, outgoing, type A person, has been suffering from ME&#x2F;CFS for 20 years. Long COVID symptoms are highly similar to ME&#x2F;CFS problems, and the hope has been that the long-underfunded ME&#x2F;CFS research would benefit from the research money that has come with COVID. Thus, I felt let down when I read the linked blurb.
评论 #38868645 未加载
评论 #38870932 未加载
评论 #38869220 未加载
radicalbyte超过 1 年前
An interesting fact: this research was paid for by crowd funding because the Ministry of Health refused to fund it. The Netherlands is also unique in Europe as the only country which does not even try to treat this condition.<p>If you get ME&#x2F;CFS you are, quite literally, left to die here. Unless someone in your network looks after you.
评论 #38870700 未加载
评论 #38873500 未加载
评论 #38869855 未加载
devjab超过 1 年前
Cool. I wonder if they’ll ever discover the reason behind the loss of smell. I lost mine completely for about a year, and I still can’t smell most things. Luckily one of the smells I got back was shit, I say lucky because it’s handy when you have diaper wearing children. In general what I’ve gotten back has been “nasty” smells, I can also smell things like vomit or rotten food. But “good” smells are still completely gone. I can’t smell flowers, I can’t smell candy and so on.<p>It never really affected me, as I apparently cared a lot less about smells than many other people, but it is a little frightening to lose something because of a disease. I’m happy it was the only side effect I got, I’d obviously rather have had none, but I’d frankly be comforted by scientists knowing more about it.
评论 #38869666 未加载
seiferteric超过 1 年前
I really wonder if we will find these symptoms are caused by other viruses as well. Possibly candidate for chronic fatigue syndrome?
评论 #38868607 未加载
评论 #38871788 未加载
funnym0nk3y超过 1 年前
Somehow I think of epigenetic processes. That COVID had an interaction with the way genes for mitochondria are transcribed. I also heard somewhere that mitochondrial dysfunction is related to psychiatric diseases, IIRC bipolar disorder or depression. Although that mechanism seems different as antidepressants and mood stabilizers don&#x27;t make a dent long COVID.
zanfr超过 1 年前
<a href="https:&#x2F;&#x2F;www.pasteur.fr&#x2F;en&#x2F;press-area&#x2F;press-documents&#x2F;covid-19-persistence-sars-cov-2-lungs-and-role-innate-immunity" rel="nofollow">https:&#x2F;&#x2F;www.pasteur.fr&#x2F;en&#x2F;press-area&#x2F;press-documents&#x2F;covid-1...</a><p>there is also the small matter of... viral persistence
reify超过 1 年前
As with any of this research into long covid, it feels deceptive to me.<p>Where is the clarity and consice exacting standards that we are supposed to be in awe of in the scientific community<p>Why is there no mention of whether or not the test subjects had been vaccinated.<p>How do we know that the vaccine did not cause the same symptoms?<p>Surely, only then, could we, I mean I, put this thinking to bed and move on.<p>For balance and clarity I would like to see the same research done on those who have had the vaccine.<p><a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=38865876">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=38865876</a> <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41467-023-44432-3" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41467-023-44432-3</a>
评论 #38875734 未加载
评论 #38876037 未加载
评论 #38883302 未加载
francisofascii超过 1 年前
I don&#x27;t think &quot;tiredness&quot; is a good word for the title. The type of symptoms experienced as post-exertional malaise is not really the same being sleepy.
评论 #38874067 未加载
LastCovidWave超过 1 年前
Stop. Getting. Infected.<p>Do MORE to stop the spread. COVID is still spreading, disabling, killing. We&#x27;re almost into year 5 of the pandemic.<p>It&#x27;s not good for yourself, your family, or your community.
rdtennent超过 1 年前
Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long-COVID has a biological cause, namely mitochondria in muscle cells that produce less energy than in healthy patients. The results of the study were published today in Nature Communications.
thenerdhead超过 1 年前
I&#x27;m sorry HN, but you continue to downplay long covid when there is evidence like this for a biological pathology right in front of you.<p>Please stop saying it is psychosomatic. Please stop saying only unfit people get it. People stop saying it is caused only by the vaccine.<p>All of these things do nothing helpful. The science will continue to push through these opinions regardless.<p>Why can&#x27;t the discussion be focused on the actual finding here which is that we have a much clearer model of what is causing PEM &#x2F; exercise intolerance in symptomatic long covid patients versus asymptomatic controls via amyloid deposits, mitochondria dysfunction, and muscle structure changes.
hirako2000超过 1 年前
Are we still trying to find some direct physical correlation betwee the symptoms of &quot;long covid&quot; and the virus infection itself?<p>Such symptoms occuring are unsurprising given the psychological effect of the pandemic at its height, its societal and economical effects.<p>Adding to this getting infected and all the fanfare, along with fear mongering we&#x27;ve been subject to via the media and mandates, long covid could alone so easily be caused by the side effects on mental health.<p>I won&#x27;t dare claiming most disease have psychological root causes, not a medical professional.
评论 #38870172 未加载
Zelphyr超过 1 年前
This connects closely with and supports Dr. Chris Palmer’s brain energy theory.
评论 #38870381 未加载
progrus超过 1 年前
Am I supposed to believe that these physiological effects have <i>nothing</i> to do with fear of the virus?<p><a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC1447278&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC1447278&#x2F;</a>
评论 #38868984 未加载
评论 #38869214 未加载