> as with many other vaccines, they do not produce sterilizing immunity<p>I wonder if the authors emphasized that as a pre-buttal to a certain political bloc. I recall a few waves of conspiratorial talking-points going around, along the lines of: "Real vaccines protect you perfectly with one dose forever, this one doesn't, wake up sheeple", etc.<p>Of course it's ahistorical nonsense: By that logic, most/all vaccines <i>ever made</i> over 200+ years were all wrongly labeled.<p>> The long-term consequence of this tolerance could be the establishment of a permissive state of the host leading to chronic infection and other unintended consequences induced by mRNA vaccination in susceptible individuals.<p>Alternately, the long-term consequence could be that the disease is still killed in a timely manner while the human is less-likely to suffer from an overreaction, like hyperinflammatory cytokine storms.<p>It gets a mention later in the discussion section:<p>> The increase in IgG4 levels [...] could reflect a tolerance mechanism that could prevent immune over-reactivity (cytokine storm) and progression to a critical stage. However, this exacerbated immune reaction does not occur in young and healthy people, and it has been documented only in older patients with genetic susceptibility and those with comorbidities.