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Proteins let cells remember how well their last division went

114 点作者 donatzsky大约 1 年前

5 条评论

The28thDuck大约 1 年前
I recall reading an article about how E. coli or elegans or something has the ability to amplify signals 1000x through nothing than a clever biological configuration. The fact that proteins have “memory” blows my mind. It’s interesting how the macro scale emulates the micro scale.
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sfryxell大约 1 年前
for me this is an example of informative back pressure. the protiens make sure the cells pay attention to what just happened to allow for changes that could improve things in the future. If you like the sound of big V8&#x27;s what&#x27;s appealing is the backpressure signaling that the engine is healthy and capable.<p>There was this article on backpressure on here and it&#x27;s been siting with me. I&#x27;ve been applying it to other articles about data flow.<p><a href="https:&#x2F;&#x2F;medium.com&#x2F;@jayphelps&#x2F;backpressure-explained-the-flow-of-data-through-software-2350b3e77ce7" rel="nofollow">https:&#x2F;&#x2F;medium.com&#x2F;@jayphelps&#x2F;backpressure-explained-the-flo...</a>
philsnow大约 1 年前
&gt; Consistent with this idea, all three of the proteins in the complex are tumor suppressors, meaning that mutations in them make tumor formation more likely. The researchers confirmed that the mitotic stopwatch was frequently defective in tumor samples.<p>It seems possible that this is not the only &#x27;stopwatch&#x27; mechanism, if some&#x2F;most tumor samples don&#x27;t have a defective version of it. If there were two or more for redundancy, then all of them being defective would make tumors more likely.
t_serpico大约 1 年前
To call this memory seems like a stretch. By the logic of the article, every daughter cell has &#x27;memory&#x27; of the parent cell because some proteins from the parent cell are present in the daughter cell. I would be curious to see p53 complex concentration as a function of cell generation&#x2F;mitosis time to show how durable this &#x27;memory&#x27; actually is.
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anthk大约 1 年前
Now cells have a carry flag?